CRS-PRO and SNOT-22 correlations with type 2 inflammatory mediators in chronic rhinosinusitis.
CRS-PRO and SNOT-22 correlations with type 2 inflammatory mediators in chronic rhinosinusitis.
复制标题
DOI：
10.1002/alr.23002
复制
发表时间：
2022-11
影响因子：
6.4
通讯作者：
Tan, Bruce K.
中科院分区：
文献类型：
--
作者：
Racette, Samuel D.;Schneider, Alexander L.;Ganesh, Meera;Huang, Julia H.;Lehmann, David S.;Price, Caroline P. E.;Rodegherio, Samuel G.;Reddy, Abhita T.;Eide, Jacob G.;Conley, David B.;Welch, Kevin C.;Kern, Robert C.;Shintani-Smith, Stephanie;Kato, Atsushi;Schleimer, Robert P.;Tan, Bruce K.
慢性鼻窦炎患者报告结果量表(CRS-PRO)中包含22个条目的鼻腔结果测试(SNT-22)和包含12个条目的患者报告结果(CRS-PRO)是CRS中经过验证的患者报告结果测量工具。在这项研究中，我们评估了内窥镜鼻窦手术(ESS)前后这些指标与2型(T2)生物标记物的相关性。收集鼻腔中黏液资料，对123例CRS患者(其中71例无鼻息肉[CRSsNP]，52例CRS伴鼻息肉[CRSwNP])在ESS术前和术后6~12个月进行鼻腔黏液-22和CRS-PRO检测。用多重珠法和酶联免疫法测定白细胞介素4、白细胞介素5、白细胞介素13和嗜酸性阳离子蛋白。用T2生物标记物比较ESS治疗前后的sNOT-22和CRS-PRO。在ESS之前，胎膜早破与任何生物标记物都不相关。ESS后CRS-Pro与两种介质(IL-5和IL-13：P分别为0.012和0.003)呈正相关，而与SNOT-22无相关性。CRSwNP患者ESS前CRS-PRO和SNOT-22与IL-4呈正相关(p=0.04)。治疗后CRS-PRO与3种标志物(IL-5、IL-13和ECP：P值分别为0.02、0.024和0.04)和SNOT-22(IL-5和IL-13：P值分别为0.038和0.02)相关。在CRSsNP患者的ESS前后，T2生物标志物中的任何一个之间没有显著的关系。对亚域的探索性分析表明，鼻科和CRS-PRO鼻科和CRS-PRO鼻科亚域与T2生物标记物有更好的相关性。在单项分析中，IL-13在ESS后与CRS-PRO上的12个条目中的8个显著相关，而在SNOT-22上的22个条目中有6个显著相关。CRS-PRO总分与T2生物标志物显着相关，尤其是在ESS术后和CRSwNP患者中。
The 22‐item Sino‐Nasal Outcome Test (SNOT‐22) and 12‐item Patient Reported Outcomes in Chronic Rhinosinusitis (CRS‐PRO) instrument are validated patient‐reported outcomes measures in CRS. In this study we assess the correlation of these with type 2 (T2) biomarkers before and after endoscopic sinus surgery (ESS). Middle meatal mucus data were collected and the SNOT‐22 and CRS‐PRO were administered to 123 patients (71 CRS without nasal polyps [CRSsNP], 52 CRS with nasal polyps [CRSwNP]) with CRS before and 6 to 12 months after undergoing ESS. Interleukin (IL)‐4, IL‐5, IL‐13, and eosinophilic cationic protein (ECP) were measured using a multiplexed bead assay and enzyme‐linked immunoassay. Pre‐ and post‐ESS SNOT‐22 and CRS‐PRO were compared with T2 biomarkers. Before ESS neither PROM correlated with any biomarker. After ESS, CRS‐PRO showed a correlation with 2 mediators (IL‐5 and IL‐13: p = 0.012 and 0.003, respectively) compared with none for the SNOT‐22. For CRSwNP patients, pre‐ESS CRS‐PRO and SNOT‐22 correlated with IL‐4 (p = 0.04 for both). However, after ESS, CRS‐PRO correlated with 3 biomarkers (IL‐5, IL‐13, and ECP: p = 0.02, 0.024, and 0.04, respectively) and SNOT‐22 with 2 biomarkers (IL‐5 and IL‐13: p = 0.038 and 0.02, respectively). There were no significant relationships between any of the T2 biomarkers pre‐ or post‐ESS among patients with CRSsNP. Exploratory analyses of the subdomains showed the SNOT‐22 rhinologic and CRS‐PRO rhinopsychologic subdomains correlated better with the T2 biomarkers. On individual item analysis, IL‐13 correlated significantly post‐ESS with 8 of 12 items on the CRS‐PRO vs 6 of 22 items on the SNOT‐22. The CRS‐PRO total score showed a significant correlation with T2 biomarkers especially when assessed post‐ESS and among CRSwNP patients.
登录
查看更多内容
影响因子：
3.4
作者：
Piccirillo, JF;Merritt, MG;Richards, ML
通讯作者：
Richards, ML
DOI：
10.1016/j.jaip.2020.04.048
发表时间：
2020-07-01
影响因子：
9.4
作者：
Ghadersohi, Saied;Price, Caroline P. E.;Tan, Bruce K.
通讯作者：
Tan, Bruce K.
DOI：
10.1016/j.jaip.2021.04.054
发表时间：
2021-08-05
影响因子：
9.4
作者：
Peters, Anju T.;Bose, Sumit;Stevens, Whitney W.
通讯作者：
Stevens, Whitney W.
影响因子：
24.3
作者：
Riechelmann, H;Deutschle, T;Bachem, M
通讯作者：
Bachem, M
影响因子：
7.2
作者：
Cook, Karon F.;Jensen, Sally E.;Cella, David
通讯作者：
Cella, David