Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica.
Additive and Interactive Associations of Environmental and Sociodemographic Factors with the Genotypes of Three Glutathione S-Transferase Genes in Relation to the Blood Arsenic Concentrations of Children in Jamaica.
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DOI：
10.3390/ijerph19010466
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发表时间：
2022-01-01
影响因子：
--
通讯作者：
Loveland KA
中科院分区：
文献类型：
--
作者：
Rahbar MH;Samms-Vaughan M;Zhao Y;Saroukhani S;Zaman SF;Bressler J;Hessabi M;Grove ML;Shakspeare-Pellington S;Loveland KA
砷（As）是一种类金属，被归类为异生物质，对人类特别是儿童具有毒性作用。由于牙买加的土壤中含有砷，饮食摄入被认为是牙买加人接触砷的主要来源。此外，谷胱甘肽S-转移酶（GST）基因，包括GSTT 1，GSTP 1，和GSTM 1，发挥了重要作用，在代谢的外源性物质，包括作为在人类。使用来自牙买加375名典型发育儿童（2-8岁）的数据，我们调查了环境和社会人口因素，以及它们与儿童GST基因型的可能相互作用，这些基因型与血液As浓度的可检测水平有关（即，>1.3微克/升）。使用多变量logistic回归，我们已经确定了与血液As浓度显著相关的环境因素，包括儿童的年龄，父母的教育水平，以及咸水鱼，卷心菜，蚕豆和鳄梨的消费量（所有p < 0.01）。基于多变量分析，包括基因x环境相互作用，我们发现，在GSTP 1 Ile 105 Val的Ile/Ile基因型的儿童中，与不吃鳄梨的儿童相比，食用鳄梨的儿童具有更高的可检测血液As浓度的几率。
Arsenic (As) is a metalloid that has been classified as a xenobiotic with toxic effects on human beings, especially on children. Since the soil in Jamaica contains As, dietary intake is considered the main source of As exposure in Jamaicans. In addition, glutathione S-transferase (GST) genes, including GSTT1, GSTP1, and GSTM1, play an important role in the metabolism of xenobiotics including As in humans. Using data from 375 typically developing children (2–8 years) in Jamaica, we investigated the environmental and sociodemographic factors, as well as their possible interactions with the children’s genotype for GST genes in relation to having a detectable level of blood As concentration (i.e., >1.3 μg/L). Using multivariable logistic regression, we have identified environmental factors significantly associated with blood As concentrations that include a child’s age, parental education levels, and the consumption of saltwater fish, cabbage, broad beans, and avocado (all p < 0.01). Based on the multivariable analysis including gene x environment interactions, we found that among children with the Ile/Ile genotype for GSTP1 Ile105Val, children who consumed avocado had higher odds of having a detectable blood As concentration compared to children who did not eat avocado.
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影响因子：
6.1
作者：
Demirkol, O;Adams, C;Ercal, N
通讯作者：
Ercal, N
影响因子：
5.6
作者：
Gonzalez-Martinez, Farith;Sanchez-Rodas, Daniel;Johnson-Restrepo, Boris
通讯作者：
Johnson-Restrepo, Boris
社会经济地位，亲子关系和学习动机对阅读能力的影响。
影响因子：
3.8
作者：
Chen Q;Kong Y;Gao W;Mo L
通讯作者：
Mo L
从胎儿超声报告中提取的生物识别测量结果，对子宫低水平暴露和胎儿生长进行了初步分析。
DOI：
10.1186/1476-069x-14-12
发表时间：
2015-03-30
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Davis MA;Higgins J;Li Z;Gilbert-Diamond D;Baker ER;Das A;Karagas MR
通讯作者：
Karagas MR
影响因子：
4.5
作者：
Del Rio M;Alvarez J;Mayorga T;Dominguez S;Sobin C
通讯作者：
Sobin C