Vasohibin-1 suppresses colon cancer.
Vasohibin-1 suppresses colon cancer.
复制标题
血管丁质-1抑制结肠癌。
DOI：
10.18632/oncotarget.3493
复制
发表时间：
2015-04-10
期刊：
影响因子：
--
通讯作者：
Peng G
中科院分区：
文献类型：
--
作者：
Liu S;Han B;Zhang Q;Dou J;Wang F;Lin W;Sun Y;Peng G
Vasohibin-1 (VASH1) is an endogenous angiogenesis inhibitor. However, the clinical relevance of VASH1 in colon cancer and its regulations on cancer angiogenesis and cancer cell biological characteristics are still unknown. Here we showed that stromal VASH1 levels were negatively correlated with tumor size, advanced clinical stage and distant metastases in colon cancer patients. Overexpression of VASH1 in colon cancer cells induced apoptosis and senescence, inhibiting cancer cell growth and colony formation in vitro and tumor growth in vivo. In addition, knockdown of VASH1 in cancer cells promoted cell growth, adhesion and migration in vitro, and enhanced tumorigenesis and metastasis in vivo.
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影响因子：
21.3
作者：
通讯作者：
--
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J
影响因子：
56.9
作者：
Peng, GY;Guo, Z;Wang, RF
通讯作者：
Wang, RF
影响因子：
6
作者：
Hosaka, Tomoko;Kimura, Hiroshi;Sato, Yasufumi
通讯作者：
Sato, Yasufumi
影响因子：
8.8
作者：
Akagi K;Ikeda Y;Miyazaki M;Abe T;Kinoshita J;Maehara Y;Sugimachi K
通讯作者：
Sugimachi K