Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapse.
Syncrip/hnRNP Q influences synaptic transmission and regulates BMP signaling at the Drosophila neuromuscular synapse.
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合成/HNRNP Q会影响突触传播，并调节果蝇神经肌肉突触的BMP信号传导。
DOI：
10.1242/bio.20149027
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发表时间：
2014-08-29
期刊：
影响因子：
2.4
通讯作者：
Davis I
中科院分区：
文献类型：
--
作者：
Halstead JM;Lin YQ;Durraine L;Hamilton RS;Ball G;Neely GG;Bellen HJ;Davis I
突触可塑性涉及通过多个通路响应于神经元活动的突触连接的调节。一种机制通过来自突触后的逆行信号调节突触传递，所述逆行信号影响突触前中囊泡释放的概率。尽管它的重要性，很少的因素所需的逆行信号的表达，和适当的突触传递，已被确定。在这里，我们确定了保守的RNA结合蛋白Syncrip作为一个新的因素，调节囊泡从运动神经元释放的效率，并需要正确的突触结构。我们表明，syncrip是需要遗传和其蛋白质产物仅在肌肉中检测到，而不是在运动神经元本身。这种意想不到的非自主性至少部分地解释了Syncrip调节从肌肉到运动神经元的逆行BMP信号的事实。我们发现Syncrip从突触后影响骨形态发生蛋白配体玻璃底船的水平，并调节突触前。我们的研究结果突出了RNA结合蛋白Syncrip作为一种新的突触输出调节器。鉴于其已知的作用，在调节翻译，我们建议，Syncrip是重要的保持突触前囊泡释放和突触后翻译的强度之间的平衡。
Synaptic plasticity involves the modulation of synaptic connections in response to neuronal activity via multiple pathways. One mechanism modulates synaptic transmission by retrograde signals from the post-synapse that influence the probability of vesicle release in the pre-synapse. Despite its importance, very few factors required for the expression of retrograde signals, and proper synaptic transmission, have been identified. Here, we identify the conserved RNA binding protein Syncrip as a new factor that modulates the efficiency of vesicle release from the motoneuron and is required for correct synapse structure. We show that syncrip is required genetically and its protein product is detected only in the muscle and not in the motoneuron itself. This unexpected non-autonomy is at least partly explained by the fact that Syncrip modulates retrograde BMP signals from the muscle back to the motoneuron. We show that Syncrip influences the levels of the Bone Morphogenic Protein ligand Glass Bottom Boat from the post-synapse and regulates the pre-synapse. Our results highlight the RNA-binding protein Syncrip as a novel regulator of synaptic output. Given its known role in regulating translation, we propose that Syncrip is important for maintaining a balance between the strength of presynaptic vesicle release and postsynaptic translation.
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