Metal nickel exposure increase the risk of congenital heart defects occurrence in offspring
Metal nickel exposure increase the risk of congenital heart defects occurrence in offspring
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金属镍暴露会增加后代发生先天性心脏病的风险
DOI：
10.1097/md.0000000000015352
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发表时间：
2019-05
期刊：
影响因子：
1.6
通讯作者：
Zhu J
中科院分区：
文献类型：
--
作者：
Nannan Zhang;Chen M;Li J;Deng Y;Li SL;Guo YX;Li NN;Lin Y;Yu P;Liu Z;Zhu J
背景：以往的研究表明，重金属暴露可增加先天性心脏病（CHD）的发生率。然而，有有限的数据之间的关系，暴露于镍和冠心病的发生在后代。本研究的目的是分析母亲镍暴露与后代患冠心病风险之间的关系。材料与方法：为探讨镍暴露与冠心病发病的关系，对490名对照组和399例冠心病患者进行了病例对照研究。本文测定了孕妇头发和胎儿胎盘组织中镍的含量，并进行Logistic回归分析，探讨镍暴露与冠心病的关系。结果：CHD组孕妇头发和胎儿胎盘组织中镍的中位浓度分别为0.629ng/mg，P <0.05（校正比值比[aOR]，1.326; 95%CI，1.003-1.757）和0.178 ng/mg，P <0.05（aOR，2.204; 95%CI，0.783-6.206）。 在不同的CHD亚型中，发镍水平也存在显著差异，包括间隔缺损（P <0.05）、圆锥动脉干缺损（P <0.05）、右心室流出道梗阻（P <0.01）和左心室流出道梗阻（P <0.05）。 在其他心脏缺陷的病例中，胎儿胎盘组织中的镍浓度有显著差异（P <0.05）。 结论：镍暴露可能与冠心病的发生有关。
Background: Previous studies have investigated heavy metal exposure could increase the occurrence of congenital heart defects (CHDs). However, there are limited data regarding the relationship between exposure to nickel and CHDs occurrence in offspring. The aim of this study was to analyze the association between nickel exposure in mothers and the risk of CHDs in offspring. Materials and methods: To explore the association of nickel exposure and occurrence of CHD, a case-control study with 490 controls and 399 cases with CHDs in China were developed. The concentrations of nickel in hair of pregnant woman and fetal placental tissue were measured and used a logistic regression analysis to explore the relationship between nickel exposure and risk of CHD. Results: The median concentrations of nickel were 0.629 ng/mg, P < .05 (adjusted odds ratio [aOR], 1.326; 95% CI, 1.003–1.757) and 0.178 ng/mg, P < .05 (aOR, 2.204; 95% CI, 0.783–6.206), in maternal hair and in fetal placental tissue in the CHD group, respectively. Significant differences in the level of nickel in hair were also found in the different CHD subtypes including septal defects (P < .05), conotruncal defects (P < .05), right ventricular outflow tract obstruction (P < .01), and left ventricular outflow tract obstruction (P < .05). Dramatically different nickel concentrations in fetal placenta tissue were found in cases with other heart defects (P < .05). Conclusions: The finding suggested that the occurrence of CHDs may be associated with nickel exposure.
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作者：
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影响因子：
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