Test-retest stability analysis of resting brain activity revealed by blood oxygen level-dependent functional MRI.
Test-retest stability analysis of resting brain activity revealed by blood oxygen level-dependent functional MRI.
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DOI：
10.1002/jmri.23670
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发表时间：
2012-08
影响因子：
4.4
通讯作者：
Wang, Ze
中科院分区：
文献类型：
--
作者：
Li, Zhengjun;Kadivar, Aniseh;Pluta, John;Dunlop, John;Wang, Ze
评估四个fMRI衍生的静息脑活动指标的重测稳定性：基于种子区域的功能连接性（SRFC）、独立成分分析（伊卡）衍生的基于网络的FC（NTFC）、区域同质性（ReHo）和低频波动幅度（ALFF）。模拟被用来评估SRFC，ReHo，和ALFF噪声干扰的敏感性。重复静息血氧水平依赖（BOLD）的功能磁共振成像获得32名健康受试者。使用类内相关系数（ICC）评估4个指标的稳定性。随机噪声产生小的随机SRFC，小但一致的ReHo和ALFF。为了减少噪声干扰，应使用大于20个体素的邻域大小来计算ReHo。无论是前扣带皮层（ACC）和后扣带皮层（PCC）为基础的SRFC是可重复的空间扩展区域比伊卡NTFC。两个区域自发脑活动（SBA）的措施，ReHo和ALFF，几乎在整个灰质的重测重现性。SRFC、ReHo和ALFF对随机噪声干扰具有鲁棒性。用于计算ReHo的邻域大小应大于20个体素。ICC>0.5和簇大小>11应用于评估ACC/PCC SRFC、ReHo和ALFF的ICC图。两个月后，可以使用ACC/PCC SRFC、ReHo和ALFF可靠地测量基于BOLD fMRI的SBA。
To assess test-retest stability of four fMRI-derived resting brain activity metrics: the seed-region-based functional connectivity (SRFC), independent component analysis (ICA)-derived network-based FC (NTFC), regional homogeneity (ReHo), and the amplitude of low frequency fluctuation (ALFF). Simulations were used to assess the sensitivity of SRFC, ReHo, and ALFF to noise interference. Repeat resting blood-oxygen-level-dependent (BOLD) fMRI were acquired from 32 healthy subjects. The intra-class correlation coefficient (ICC) was used to assess the stability of the 4 metrics. Random noise yielded small random SRFC, small but consistent ReHo and ALFF. A neighborhood size greater than 20 voxels should be used for calculating ReHo in order to reduce the noise interference. Both the anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC)-based SRFC were reproducible in more spatially extended regions than ICA NTFC. The two regional spontaneous brain activity (SBA) measures, ReHo and ALFF, showed test-retest reproducibility in almost the whole grey matter. SRFC, ReHo, and ALFF are robust to random noise interference. The neighborhood size for calculating ReHo should be larger than 20 voxels. ICC>0.5 and cluster size>11 should be used to assess the ICC maps for ACC/PCC SRFC, ReHo and ALFF. BOLD fMRI-based SBA can be reliably measured using ACC/PCC SRFC, ReHo and ALFF after two months.
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DOI：
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发表时间：
2005-07-05
影响因子：
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作者：
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