Investigating the Effects of Physical Therapy Timing, Intensity and Duration on Post-Traumatic Joint Contracture in a Rat Elbow Model.
Investigating the Effects of Physical Therapy Timing, Intensity and Duration on Post-Traumatic Joint Contracture in a Rat Elbow Model.
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DOI：
10.32098/mltj.03.2021.20
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Lake SP
中科院分区：
文献类型：
--
作者：
Reiter AJ;Castile RM;Schott HR;Kivitz GJ;Chamberlain AM;Lake SP
创伤后关节挛缩（PTJC），其特征是活动度丧失和永久性僵硬，影响高达50%的肘关节脱位或骨折患者。旨在预防肘关节PTJC和避免手术治疗的成功保守治疗方法的机制（例如，物理治疗）知之甚少。使用先前建立的肘关节PTJC大鼠模型，本研究的目的是探讨不同的时间，强度和持续时间的主动功能锻炼对关节运动结果的影响。大鼠单侧肘关节脱位后，受伤的肢体用绷带固定42天，然后再自由活动42天，产生长期PTJC。这项工作总结了几项研究（I-III期），研究了早期与延迟治疗（时机），自由活动与强迫跑步机行走（强度），以及有限时间与无限使用（持续时间）对肘关节PTJC的影响。与未治疗的受伤动物相比，治疗组中的关节运动结果显示，无论时间、强度或持续时间如何，在损伤后第14天或之后开始治疗时，均无改善。只有在伤后第3天永久拆除绷带时，关节活动范围才能得到改善，无论是否进行了额外的跑步机行走。早期活动对于维持创伤性肘关节损伤后的活动范围至关重要。
Post-traumatic joint contracture (PTJC), characterized by loss of motion and permanent stiffness, affects up to 50% of patients following elbow joint dislocation or fracture. Mechanisms governing successful conservative treatment methods aimed at preventing elbow PTJC and avoiding operative treatments (e.g., physical therapy) are poorly understood. Using a previously established rat model of elbow PTJC, the purpose of this study was to explore the effect of varying timing, intensity and duration of active, functional exercise on joint motion outcomes. Following a surgically-induced unilateral elbow dislocation in rats, injured limbs were immobilized in bandages for 42 days followed by free mobilization for 42 additional days producing long-term PTJC. This work summarizes several studies (Phases I-III) that investigated the effects of early versus delayed therapy (timing), free mobilization versus forced treadmill walking (intensity), and limited-time versus unlimited use (duration) on elbow PTJC. Joint motion outcomes in therapy groups showed no improvements compared to non-treated injured animals when therapy began day 14 post-injury or later regardless of timing, intensity or duration. Improved joint range-of-motion was only achieved when bandages were permanently removed at day 3 post-injury, regardless of whether added treadmill walking was performed. Early motion is essential to preserving range-of-motion following traumatic elbow injury in a rat model.
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影响因子：
1.8
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1111/j.1600-0838.2004.382.x
发表时间：
2004-06-01
影响因子：
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影响因子：
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作者：
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通讯作者：
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