Role of the basal ganglia in the control of sleep and wakefulness.

Role of the basal ganglia in the control of sleep and wakefulness.
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DOI:
10.1016/j.conb.2013.02.001
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发表时间:
2013-10
影响因子:
5.7
通讯作者:
Huang ZL
Huang ZL
中科院分区:
医学2区
文献类型:
--
作者:
Lazarus M;Chen JF;Urade Y;Huang ZL

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基底节(BG)起着调节运动功能、习惯形成和奖赏/成瘾行为的凝聚功能单位的作用;但关于BG如何保持清醒和抑制睡眠以实现BG的所有这些基本功能的争论直到最近才开始。神经毒性损伤、药理学方法和对转基因动物的行为分析表明,纹状体和苍白球对于控制睡眠和觉醒很重要。在这里,我们讨论了BG睡眠-觉醒调节的解剖学和分子机制,并提出了一个合理的模型,在该模型中,伏隔核通过腺苷和多巴胺受体将行为过程与觉醒相结合。
The basal ganglia (BG) act as a cohesive functional unit that regulates motor function, habit formation, and reward/addictive behaviors; but the debate has only recently started on how the BG maintain wakefulness and suppress sleep to achieve all these fundamental functions of the BG. Neurotoxic lesioning, pharmacological approaches, and the behavioral analyses of genetically modified animals revealed that the striatum and globus pallidus are important for the control of sleep and wakefulness. Here, we discuss anatomical and molecular mechanisms for sleep-wake regulation in the BG and propose a plausible model in which the nucleus accumbens integrates behavioral processes with wakefulness through adenosine and dopamine receptors.
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