Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts.
Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts.
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DOI：
10.3390/ijms140713782
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发表时间：
2013-07-03
影响因子：
5.6
通讯作者：
Aronson WJ
中科院分区：
文献类型：
--
作者：
Galet C;Gray A;Said JW;Castor B;Wan J;Beltran PJ;Calzone FJ;Elashoff D;Cohen P;Aronson WJ
Calorie restriction (CR) inhibits prostate cancer progression, partially through modulation of the IGF axis. IGF-1 receptor (IGF-1R) blockade reduces prostate cancer xenograft growth. We hypothesized that combining calorie restriction with IGF-1R blockade would have an additive effect on prostate cancer growth. Severe combined immunodeficient mice were subcutaneously injected with 22Rv1 cells and randomized to: (1) Ad libitum feeding/intraperitoneal saline (Ad-lib); (2) Ad-lib/20 mg/kg twice weekly, intraperitoneal ganitumab [anti-IGF-1R antibody (Ad-lib/Ab)]; (3) 40% calorie restriction/intraperitoneal saline (CR); (4) CR/ intraperitoneal ganitumab, (CR/Ab). CR and ganitumab treatment were initiated one week after tumor injection. Euthanasia occurred 19 days post treatment. Results showed that CR alone decreased final tumor weight, plasma insulin and IGF-1 levels, and increased apoptosis. Ganitumab therapy alone reduced tumor growth but had no effect on final tumor weight. The combination therapy (CR/Ab) further decreased final tumor weight and proliferation, increased apoptosis in comparison to the Ad-lib group, and lowered plasma insulin levels relative to the Ad-lib and Ad-lib/Ab groups. Tumor AKT activation directly correlated with plasma IGF-1 levels. In conclusion, whereas ganitumab therapy modestly affected 22Rv1 tumor growth, combining IGF-1R blockade with calorie restriction resulted in a significant decrease in final tumor weight and improved metabolic profile.
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影响因子：
5.7
作者：
Konijeti R;Koyama S;Gray A;Barnard RJ;Said JW;Castor B;Elashoff D;Wan J;Beltran PJ;Calzone FJ;Cohen P;Galet C;Aronson WJ
通讯作者：
Aronson WJ
影响因子：
56.9
作者：
Chan, JM;Stampfer, MJ;Pollak, M
通讯作者：
Pollak, M
影响因子：
11.5
作者：
Chitnis, Meenali M.;Yuen, John S. P.;Macaulay, Valentine M.
通讯作者：
Macaulay, Valentine M.
影响因子：
2.3
作者：
Ngo, TH;Barnard, RJ;Aronson, WJ
通讯作者：
Aronson, WJ
影响因子：
10.3
作者：
Mukherjee, P;Sotnikov, AV;Clinton, SK
通讯作者：
Clinton, SK