The Evolution of Aggregative Multicellularity and Cell-Cell Communication in the Dictyostelia.
The Evolution of Aggregative Multicellularity and Cell-Cell Communication in the Dictyostelia.
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DOI：
10.1016/j.jmb.2015.08.008
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发表时间：
2015-11-20
影响因子：
5.6
通讯作者：
Schaap, Pauline
中科院分区：
文献类型：
--
作者：
Du, Qingyou;Kawabe, Yoshinori;Schilde, Christina;Chen, Zhi-hui;Schaap, Pauline
聚集体多细胞，导致孢子子实体的形成，在真核生物和原核生物中至少独立进化了六次。在真核生物中，这种形式的多细胞生物主要研究于群居变形虫盘齿骨变形虫。在这篇综述中，我们总结了四种主要盘齿钢菌群中细胞类型特化和行为复杂性的进化趋势。我们描述了控制盘状豆科植物发育程序的细胞-细胞通信系统，强调了cAMP在细胞运动和细胞分化调节中的核心作用。比较基因组学研究表明，参与cAMP信号传导的蛋白质在盘齿柱菌及其单细胞变形虫祖先中是高度保守的。比较功能分析表明，盘状棘球蚴的cAMP信号转导起源于阿米巴虫胞内的第二信使作用。我们强调了cAMP信号基因的一些分子变化，这些变化负责cAMP在多细胞发育中的新作用。许多真核生物和原核生物聚集在一起形成一个群落，其中细胞共同构成子实体。群体感应、双组分信号和环核苷酸cAMP和c-di-GMP介导的信号在原核生物的社会行为中起着重要作用。类似的信号传导机制也调节真核生物盘状盘基骨菌子实体形成过程中的聚集和细胞类型特化。比较基因组学和基因功能分析表明，控制盘基骨菌发育的cAMP和双组分信号机制起源于单细胞祖先的应激反应。
Aggregative multicellularity, resulting in formation of a spore-bearing fruiting body, evolved at least six times independently amongst both eukaryotes and prokaryotes. Amongst eukaryotes, this form of multicellularity is mainly studied in the social amoeba Dictyostelium discoideum. In this review, we summarise trends in the evolution of cell-type specialisation and behavioural complexity in the four major groups of Dictyostelia. We describe the cell–cell communication systems that control the developmental programme of D. discoideum, highlighting the central role of cAMP in the regulation of cell movement and cell differentiation. Comparative genomic studies showed that the proteins involved in cAMP signalling are deeply conserved across Dictyostelia and their unicellular amoebozoan ancestors. Comparative functional analysis revealed that cAMP signalling in D. discoideum originated from a second messenger role in amoebozoan encystation. We highlight some molecular changes in cAMP signalling genes that were responsible for the novel roles of cAMP in multicellular development. Many eukaryotes and prokaryotes aggregate to form a community in which cells together construct a fruiting body. Quorum sensing, two-component signalling and signalling mediated by the cyclic nucleotides cAMP and c-di-GMP play major roles in the social behaviour of prokaryotes. Similar signalling mechanisms also regulate aggregation and cell-type specialisation during fruiting body formation in the eukaryote Dictyostelium discoideum. Comparative genomic and gene functional analysis revealed that the cAMP and two-component signalling mechanisms that control Dictyostelium development originated from a stress response in the unicellular ancestors.
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影响因子：
21.3
作者：
通讯作者：
--
腺苷酸环化酶R的功能解剖，这是孢子封装的诱导剂。
DOI：
10.1074/jbc.m110.156380
发表时间：
2010-12-31
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Chen ZH;Schilde C;Schaap P
通讯作者：
Schaap P
DOI：
10.1073/pnas.0502238102
发表时间：
2005-05-03
影响因子：
11.1
作者：
Alvarez-Curto, E;Rozen, DE;Schaap, P
通讯作者：
Schaap, P
影响因子：
56.9
作者：
Hirose, Shigenori;Benabentos, Rocio;Shaulsky, Gad
通讯作者：
Shaulsky, Gad
影响因子：
3
作者：
ERDOS, GW;RAPER, KB
通讯作者：
RAPER, KB