Training-induced plasticity of auditory localization in adult mammals.
Training-induced plasticity of auditory localization in adult mammals.
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DOI：
10.1371/journal.pbio.0040071
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发表时间：
2006-04
期刊：
影响因子：
9.8
通讯作者：
King AJ
中科院分区：
文献类型：
--
作者：
Kacelnik O;Nodal FR;Parsons CH;King AJ
准确的听觉定位依赖于基于每只耳朵声波中存在的空间线索的神经计算。这些线索的价值取决于两只耳朵的大小、形状和距离，因此可能因人而异。与其他感知技能一样，与空间听力有关的神经回路在发育过程中受到经验的影响，并在以后的生活中保留一些可塑性。然而，促成和促进成人大脑听觉定位可塑性的因素尚不清楚。在这里，我们发现成熟的雪貂可以通过可逆地封闭一只耳朵来改变它们的空间线索后，迅速重新学习声音的定位，但前提是它们被训练在行为相关的任务中使用这些线索，并且训练频率越高，效果越好。我们还发现，在没有视觉或错误反馈的情况下，听觉适应是可能的。最后，我们证明了这个过程涉及到灵敏度的转变，从异常的听觉空间线索到受耳塞影响较小的其他线索。因此，成熟的听觉系统能够通过重新加权不同的定位线索来适应异常的空间信息。这些结果表明，训练应促进听力受损者对助听器的适应。经过行为相关任务的训练后，成年雪貂通过重新衡量刺激中不太扭曲的频谱线索，迅速适应改变的听觉定位线索。
Accurate auditory localization relies on neural computations based on spatial cues present in the sound waves at each ear. The values of these cues depend on the size, shape, and separation of the two ears and can therefore vary from one individual to another. As with other perceptual skills, the neural circuits involved in spatial hearing are shaped by experience during development and retain some capacity for plasticity in later life. However, the factors that enable and promote plasticity of auditory localization in the adult brain are unknown. Here we show that mature ferrets can rapidly relearn to localize sounds after having their spatial cues altered by reversibly occluding one ear, but only if they are trained to use these cues in a behaviorally relevant task, with greater and more rapid improvement occurring with more frequent training. We also found that auditory adaptation is possible in the absence of vision or error feedback. Finally, we show that this process involves a shift in sensitivity away from the abnormal auditory spatial cues to other cues that are less affected by the earplug. The mature auditory system is therefore capable of adapting to abnormal spatial information by reweighting different localization cues. These results suggest that training should facilitate acclimatization to hearing aids in the hearing impaired. After training on a behaviorally relevant task, adult ferrets rapidly adapt to altered auditory localization cues by reweighing the less distorted spectral cues of the stimulus.
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影响因子：
64.8
作者：
Ahissar, M;Hochstein, S
通讯作者：
Hochstein, S
影响因子：
2.8
作者：
Hartley, DEH;Moore, DR
通讯作者：
Moore, DR
DOI：
10.1073/pnas.092278099
发表时间：
2002-07-23
影响因子：
11.1
作者：
Blake, DT;Strata, F;Merzenich, MM
通讯作者：
Merzenich, MM
影响因子：
1.8
作者：
FAHLE, M;EDELMAN, S;POGGIO, T
通讯作者：
POGGIO, T
影响因子：
2.8
作者：
KELLY, JB;KAVANAGH, GL;DALTON, JCH
通讯作者：
DALTON, JCH