Investigation of Sex Differences in the Microglial Response to Binge Ethanol and Exercise.
Investigation of Sex Differences in the Microglial Response to Binge Ethanol and Exercise.
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DOI：
10.3390/brainsci7100139
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发表时间：
2017-10-24
期刊：
影响因子：
3.3
通讯作者：
Leasure JL
中科院分区：
文献类型：
--
作者：
Barton EA;Baker C;Leasure JL
女性的大脑似乎有选择地容易受到酒精的神经毒性影响，但原因尚不清楚。一种可能性是女性大脑中的神经免疫反应过度，例如酒精增加了小胶质细胞的数量和对随后刺激（如运动）的反应性。重要的是要更好地描述酒精和运动的相互作用的神经效应，因为运动越来越多地被用于治疗酒精使用障碍。本研究比较了酗酒和/或运动后雄性和雌性大鼠大脑酒精敏感区域（内侧前额叶皮层和海马）小胶质细胞的数量及其激活的证据。酗酒增加了小胶质细胞的数量和形态特征，这与女性大脑中的激活一致，但与男性无关，无论运动如何。酗酒后运动确实增加了女性MHC II+（免疫活性）小胶质细胞的数量，尽管绝大多数小胶质细胞不表达MHC II。这些结果表明，酗酒对小胶质细胞产生性别特异性影响，可能导致对随后挑战的反应增强，部分原因是女性大脑对酒精的明显选择性脆弱性。
The female brain appears selectively vulnerable to the neurotoxic effects of alcohol, but the reasons for this are unclear. One possibility is an exaggerated neuroimmune response in the female brain, such that alcohol increases microglia number and reactivity to subsequent stimuli, such as exercise. It is important to better characterize the interactive neural effects of alcohol and exercise, as exercise is increasingly being used in the treatment of alcohol use disorders. The present study compared the number of microglia and evidence of their activation in alcohol-vulnerable regions of the brain (medial prefrontal cortex and hippocampus) in male and female rats following binge alcohol and/or exercise. Binge alcohol increased microglia number and morphological characteristics consistent with their activation in the female brain but not the male, regardless of exercise. Binge alcohol followed by exercise did increase the number of MHC II+ (immunocompetent) microglia in females, although the vast majority of microglia did not express MHC II. These results indicate that binge alcohol exerts sex-specific effects on microglia that may result in enhanced reactivity to a subsequent challenge and in part underlie the apparent selective vulnerability of the female brain to alcohol.
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影响因子：
--
作者：
Agartz, I;Momenan, R;Hommer, DW
通讯作者：
Hommer, DW
影响因子：
2.3
作者：
Agartz, I;Shoaf, S;Hommer, DW
通讯作者：
Hommer, DW
影响因子：
3.7
作者：
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通讯作者：
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DOI：
10.1016/j.bbi.2015.10.003
发表时间：
2016-02
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Bollinger JL;Bergeon Burns CM;Wellman CL
通讯作者：
Wellman CL
影响因子：
5.3
作者：
Doyle, Hillary H.;Eidson, Lori N.;Murphy, Anne Z.
通讯作者：
Murphy, Anne Z.