Natural and Synthetic Saponins as Vaccine Adjuvants.
Natural and Synthetic Saponins as Vaccine Adjuvants.
复制标题
天然和合成皂苷作为疫苗佐剂。
DOI：
10.3390/vaccines9030222
复制
发表时间：
2021-03-05
期刊：
影响因子：
7.8
通讯作者：
Wang P
中科院分区：
文献类型：
--
作者：
Wang P
皂苷佐剂已被广泛研究用于兽医和人类疫苗。其中，QS-21由于其独特的免疫刺激活性而脱颖而出，诱导平衡的Th 1/Th 2免疫，这对于对抗各种微生物病原体，癌症和其他疾病的广泛应用是有价值的。它最近已被批准用于人疫苗中作为组合佐剂的关键组分，AS 01 b in Shingrix®治疗带状疱疹。尽管QS-21在研究和临床上是有用的，但对QS-21和其他皂苷佐剂的细胞和分子机制知之甚少。已经投入了大量的努力来研究以理解QS-21在不同制剂中和与其他佐剂的不同组合中的机制，并且投入了药物化学研究以获得机制见解和开发可以规避其固有缺点的QS-21的实际替代品。本文简要介绍了QS-21的佐剂作用机制，以及近年来结构-活性-关系（SAR）研究的成果。
Saponin adjuvants have been extensively studied for their use in veterinary and human vaccines. Among them, QS-21 stands out owing to its unique profile of immunostimulating activity, inducing a balanced Th1/Th2 immunity, which is valuable to a broad scope of applications in combating various microbial pathogens, cancers, and other diseases. It has recently been approved for use in human vaccines as a key component of combination adjuvants, e.g., AS01b in Shingrix® for herpes zoster. Despite its usefulness in research and clinic, the cellular and molecular mechanisms of QS-21 and other saponin adjuvants are poorly understood. Extensive efforts have been devoted to studies for understanding the mechanisms of QS-21 in different formulations and in different combinations with other adjuvants, and to medicinal chemistry studies for gaining mechanistic insights and development of practical alternatives to QS-21 that can circumvent its inherent drawbacks. In this review, we briefly summarize the current understandings of the mechanism underlying QS-21’s adjuvanticity and the encouraging results from recent structure-activity-relationship (SAR) studies.
登录
查看更多内容
影响因子：
6.2
作者：
Bode C;Zhao G;Steinhagen F;Kinjo T;Klinman DM
通讯作者：
Klinman DM
影响因子：
7.3
作者：
Awate S;Babiuk LA;Mutwiri G
通讯作者：
Mutwiri G
影响因子：
16.6
作者：
Deng, Kai;Adams, Michelle M.;Gin, David Y.
通讯作者：
Gin, David Y.
影响因子：
4.6
作者：
Detienne S;Welsby I;Collignon C;Wouters S;Coccia M;Delhaye S;Van Maele L;Thomas S;Swertvaegher M;Detavernier A;Elouahabi A;Goriely S;Didierlaurent AM
通讯作者：
Didierlaurent AM
影响因子：
7.8
作者：
Di Pasquale A;Preiss S;Tavares Da Silva F;Garçon N
通讯作者：
Garçon N