Deficits in sentence expression in amyotrophic lateral sclerosis.
Deficits in sentence expression in amyotrophic lateral sclerosis.
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DOI：
10.3109/21678421.2014.974617
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发表时间：
2015-03
影响因子：
2.8
通讯作者：
Grossman M
中科院分区：
文献类型：
--
作者：
Ash S;Olm C;McMillan CT;Boller A;Irwin DJ;McCluskey L;Elman L;Grossman M
肌萎缩侧索硬化症（ALS）的言语产生的定量检查是罕见的。为了确定语言功能最小混淆的运动障碍，我们调查了语言和运动的ALS受损的句子表达的来源，我们相关的赤字灰质（GM）和白色物质（WM）的MRI异常。我们分析了26名ALS患者和19名健康老年人的运动和语言相关缺陷的半结构化语音样本。回归分析与GM萎缩和WM各向异性分数（FA）降低相关的语法性。结果表明，ALS患者受损相对于控制的语音量，语音速率，语音清晰度错误，和语法。语速和发音错误与患者的运动障碍有关，而语法困难与运动困难无关。这在没有构音障碍和执行缺陷的亚组中得到证实。回归相关的语法表达GM萎缩在左下额和前颞区和减少FA在上级纵向和下额枕束。总之，ALS患者在句子表达方面表现出多因素缺陷。他们表现出语法表达的缺陷，这是独立于他们的运动障碍。语法表达受损与句法处理相关的大脑区域网络中的疾病有关。
Quantitative examinations of speech production in amyotrophic lateral sclerosis (ALS) are rare. To identify language features minimally confounded by a motor disorder, we investigated linguistic and motor sources of impaired sentence expression in ALS, and we related deficits to gray matter (GM) and white matter (WM) MRI abnormalities. We analyzed a semi-structured speech sample in 26 ALS patients and 19 healthy seniors for motor- and language-related deficits. Regression analyses related grammaticality to GM atrophy and reduced WM fractional anisotropy (FA). Results demonstrated that ALS patients were impaired relative to controls on quantity of speech, speech rate, speech articulation errors, and grammaticality. Speech rate and articulation errors were related to the patients’ motor impairment, while grammatical difficulty was independent of motor difficulty. This was confirmed in subgroups without dysarthria and without executive deficits. Regressions related grammatical expression to GM atrophy in left inferior frontal and anterior temporal regions and to reduced FA in superior longitudinal and inferior frontal-occipital fasciculi. In conclusion, patients with ALS exhibit multifactorial deficits in sentence expression. They demonstrate a deficit in grammatical expression that is independent of their motor disorder. Impaired grammatical expression is related to disease in a network of brain regions associated with syntactic processing.
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