Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders.
Role of α6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders.
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DOI：
10.1016/j.bcp.2011.06.001
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发表时间：
2011-10-15
影响因子：
5.8
通讯作者：
Grady SR
中科院分区：
文献类型：
--
作者：
Quik M;Perez XA;Grady SR
虽然是烟碱乙酰胆碱受体（nAChR）家族的一个相对较新的成员，但大量证据表明，含α6的nAChR在CNS功能中起关键作用。这种亚型是独特的，在其相对有限的本地化的视觉系统和儿茶酚胺能途径。后者包括中脑边缘和黑质纹状体多巴胺能系统，这可能是含α6的nAChR参与尼古丁的奖励特性和运动的原因。在这里，我们回顾了文献的作用，α6含有nAChRs的重点是纹状体和延髓核。这包括在对照和损伤动物模型以及不同遗传模型中的分子、电生理和行为研究。越来越多的证据表明，黑质纹状体和中脑边缘多巴胺系统中主要的含α6的nAChR亚型是α6β2β3和α6α4β2β3 nAChR群体。它们似乎在调节多巴胺释放中起主导作用，从而影响nAChR调节的多巴胺能功能，如强化和运动行为。总之，这些数据表明，针对含有nAChR的α6的药物可能有利于治疗成瘾和具有运动缺陷的神经系统疾病，如帕金森病。
Although a relative newcomer to the nicotinic acetylcholine receptor (nAChR) family, substantial evidence suggests that α6 containing nAChRs play a key role in CNS function. This subtype is unique in its relatively restricted localization to the visual system and catecholaminergic pathways. These latter include the mesolimbic and nigrostriatal dopaminergic systems, which may account for the involvement of α6 containing nAChRs in the rewarding properties of nicotine and in movement. Here, we review the literature on the role of α6 containing nAChRs with a focus on the striatum and nucleus accumbens. This includes molecular, electrophysiological and behavioral studies in control and lesioned animal models, as well as in different genetic models. Converging evidence suggest that the major α6 containing nAChRs subtypes in the nigrostriatal and mesolimbic dopamine system are the α6β2β3 and α6α4β2β3 nAChR populations. They appear to have a dominant role in regulating dopamine release, with consequent effects on nAChR-modulated dopaminergic functions such as reinforcement and motor behavior. Altogether these data suggest that drugs directed to α6 containing nAChRs may be of benefit for the treatment of addiction and for neurological disorders with locomotor deficits such as Parkinson’s disease.
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影响因子：
4.7
作者：
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通讯作者：
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影响因子：
3.6
作者：
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通讯作者：
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DOI：
10.1124/jpet.108.145292
发表时间：
2009-02-01
影响因子：
3.5
作者：
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作者：
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通讯作者：
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哺乳动物烟碱乙酰胆碱受体：从结构到功能。
影响因子：
33.6
作者：
Albuquerque EX;Pereira EF;Alkondon M;Rogers SW
通讯作者：
Rogers SW