Individual predictors of the subjective effects of intravenous cocaine.
Individual predictors of the subjective effects of intravenous cocaine.
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DOI：
10.1016/j.psychres.2013.05.028
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发表时间：
2013-08-15
影响因子：
11.3
通讯作者：
DeSouza, Cherilyn
中科院分区：
文献类型：
--
作者：
Grasing, Kenneth;Mathur, Deepan;Newton, Thomas F.;DeSouza, Cherilyn
成瘾物质的主观效果和强化效果因人而异。这项研究比较了基线吸毒、渴望、压力生活事件和社会因素在确定可卡因对个体参与者的主观影响方面的相对贡献。十二名符合可卡因依赖标准的退伍军人在实验室环境中接受了评估。在单盲和双盲安慰剂对照注射后记录静脉注射可卡因主观效应的自我报告。可卡因的积极主观效应增加，包括药物引起的“良好”效应和静脉注射的价值，与通过成瘾严重程度指数衡量的更大的家庭和社会功能障碍密切相关。社交功能障碍是可卡因引起的欣快感最强的预测因素，约占其变异性的一半。对目前婚姻状况不满意的参与者报告说，可卡因几乎没有“不良”影响，但相反，报告称药物引起的“兴奋”、欣快感和注射价值增加。尽管需要进一步的研究来确定这种关联的普遍性，但我们的研究结果与最近的临床前结果相似，表明社交互动可以减弱精神兴奋剂的奖励。依赖于社会功能改善的药物滥用治疗效果可能是通过改变可卡因的奖励效果的大脑强化系统的变化来调节的。
The subjective and reinforcing effects of addictive substances can vary greatly between individuals. This study compared the relative contributions of baseline drug use, craving, stressful life events, and social factors in determining the subjective effects of cocaine in individual participants. Twelve veterans meeting criteria for cocaine dependence were evaluated in a laboratory setting. Self-report of the subjective effects of intravenous cocaine was recorded following single- and double- blind, placebo-controlled injections. Increased positive subjective effects of cocaine, including drug-induced ‘good’ effects and the value of intravenous injections, were most strongly correlated with greater family and social dysfunction measured through the Addiction Severity Index. Social dysfunction was the strongest predictor of cocaine-induced euphoria, accounting for approximately one-half of its variability. Participants who were dissatisfied with their current marital status reported almost no ‘bad’ effects of cocaine but instead reported increased drug-induced ‘high’, euphoria, and injection value. Although further research is required to determine the generalizability of this association, our findings are parallel to recent preclinical results showing that social interaction can attenuate psychostimulant reward. Effects of substance abuse treatment that rely on improved social function may be mediated through changes in the brain’s reinforcement system that modify the rewarding effects of cocaine.
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影响因子：
3.4
作者：
Johns, Josephine M.;McMurray, Matthew S.;Joyner, Paul W.;Jarrett, Thomas M.;Williams, Sarah K.;Cox, Elizabeth T.;Black, Mitchell A.;Middleton, Christopher L.;Walker, Cheryl H.
通讯作者：
Walker, Cheryl H.
DOI：
10.1523/jneurosci.0637-11.2011
发表时间：
2011-07-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Miczek KA;Nikulina EM;Shimamoto A;Covington HE 3rd
通讯作者：
Covington HE 3rd
影响因子：
7.6
作者：
Adinoff, Bryon;Devous, Michael D., Sr.;Cullum, Munro
通讯作者：
Cullum, Munro
影响因子：
5
作者：
Ellenbroek, BA;van der Kam, EL;Cools, AR
通讯作者：
Cools, AR
影响因子：
2.7
作者：
KOSTEN, TR;JALALI, B;KLEBER, HD
通讯作者：
KLEBER, HD