Effects of chronic and intermittent cocaine treatment on dominance, aggression, and oxytocin levels in post-lactational rats.
Effects of chronic and intermittent cocaine treatment on dominance, aggression, and oxytocin levels in post-lactational rats.
复制标题
DOI：
10.1007/s00213-010-1877-9
复制
发表时间：
2010-08
影响因子：
3.4
通讯作者：
Walker, Cheryl H.
中科院分区：
文献类型：
--
作者：
Johns, Josephine M.;McMurray, Matthew S.;Joyner, Paul W.;Jarrett, Thomas M.;Williams, Sarah K.;Cox, Elizabeth T.;Black, Mitchell A.;Middleton, Christopher L.;Walker, Cheryl H.
很少有人知道的机制，潜在的雌性啮齿动物的攻击在产后后期没有幼崽。可卡因治疗的女性的侵略，优势，催产素（OT）的反应的研究很少。本研究的目的是研究优势（饮酒成功）和侵略的限制获得饮水模型的水竞争。在产后第36天（PPD）在几个感兴趣的脑区域进行急性OT水平测量。在试验前10-30天停止可卡因治疗后，在PPD 31-35期间对断奶后10天的慢性和间歇性可卡因和生理盐水治疗和未治疗大鼠（无幼崽）进行试验。受试者被禁水过夜，三组包括未治疗的对照组（UN）、长期连续盐水治疗组（CS）和长期连续可卡因治疗组（CC;整个妊娠期30 mg/kg/天）或UN、间歇性盐水处理（IS）和间歇性可卡因处理（IC; 30 mg/kg，连续两天，在整个妊娠期间每4天一次，直至PPD 20）连续5天在5分钟的时间段内对雌性动物进行攻击和饮酒行为测试。检测杏仁核、内侧视前区（MPOA）和腹侧被盖区的OT水平。CC和IC女性比对照组更具侵略性，但只有IC女性比对照组更经常喝酒。OT水平低于MPOA的IC和CC女性比对照组。研究结果表明，长期停止治疗后，CC-和IC-治疗的非哺乳期女性（没有幼崽）有较高的侵略率，改变饮酒行为，并急剧降低MPOA OT水平。
Little is known about mechanisms underlying female rodent aggression during the late postpartum period with no pups present. Studies of aggression, dominance, and oxytocin (OT) response in cocaine-treated females are sparse. This study was designed to examine dominance (drinking success) and aggression in a limited-access drinking model of water competition. Acute OT level measures were made on postpartum day (PPD) 36 in several brain regions of interest. Chronic and intermittent cocaine- and saline-treated and untreated rats 10 days post-weaning were tested (without pups) over PPDs 31–35 following cessation of cocaine treatment 10–30 days before testing. Subjects were water-deprived overnight, and triads consisting of an untreated control (UN), a chronic continuous saline-treated (CS), and chronic continuous cocaine-treated (CC; 30 mg/kg/day throughout gestation) or a UN, an intermittent saline-treated (IS), and an intermittent cocaine-treated (IC; 30 mg/kg two consecutive days every 4 days throughout gestation until PPD 20) female were tested for aggression and drinking behavior during 5 min sessions on five consecutive days. The amygdala, medial preoptic area (MPOA), and ventral tegmental area were assayed for OT levels. CC and IC females were more aggressive than controls, but only IC females drank more often than controls. OT levels were lower in the MPOA of IC and CC females than in controls. Findings demonstrate that long after cessation of treatment, CC- and IC-treated non-lactating females (no pups present) had higher rates of aggression, altered drinking behavior, and acutely lower MPOA OT levels.
登录
查看更多内容
DOI：
10.1111/j.1749-6632.1992.tb34382.x
发表时间：
1992-06-12
期刊：
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES-SERIES
影响因子：
--
作者：
FERRIS, CF;FOOTE, KB;INSEL, TR
通讯作者：
INSEL, TR
影响因子：
2.9
作者：
Jarrett, T. M.;McMurray, M. S.;Johns, J. M.
通讯作者：
Johns, J. M.
影响因子：
3.4
作者：
DARMANI, NA;HADFIELD, MG;MARTIN, BR
通讯作者：
MARTIN, BR
影响因子：
2.9
作者：
HEYSER, CJ;MOLINA, VA;SPEAR, LP
通讯作者：
SPEAR, LP
影响因子：
2.9
作者：
Giovenardi, M;Padoin, MJ;Lucion, AB
通讯作者：
Lucion, AB