A dietary pattern derived to correlate with estrogens and risk of postmenopausal breast cancer.
A dietary pattern derived to correlate with estrogens and risk of postmenopausal breast cancer.
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DOI：
10.1007/s10549-011-1942-z
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发表时间：
2012-04
影响因子：
3.8
通讯作者：
Holmes, Michelle D.
中科院分区：
文献类型：
--
作者：
Fung, Teresa T.;Schulze, Matthias B.;Hu, Frank B.;Hankinson, Susan E.;Holmes, Michelle D.
循环雌激素是乳腺癌的既定危险因素，一些数据表明饮食可能会影响雌激素水平。因此，使用来自大型队列的女性子样本（n=550），我们应用降序回归来确定与雌二醇和硫酸雌酮相关的饮食模式。然后，我们调整了该模式以用于整个队列（n=67,802），并前瞻性评估其与绝经后乳腺癌的关联。雌激素食物模式的特点是红肉、豆类和披萨的摄入量较高，但咖啡和全谷物的摄入量较低，与雌二醇（r=0.14）和硫酸雌酮（r=0.20）有适度但显着的相关性。在 22 年的随访中，我们确定了 4,596 例乳腺癌，其中 2,938 例雌激素受体阳性肿瘤和 689 例雌激素受体阴性肿瘤。然而，在调整潜在的混杂因素后，我们没有观察到与总体、雌激素受体阳性或雌激素受体阴性乳腺癌的任何关联。总之，饮食模式似乎与雌激素只有适度的关联，与绝经后乳腺癌风险无关。尽管这些结果无效，但应该在其他人群中重复进行，因为食物摄入量的差异可能会产生与雌激素有更强关联的饮食模式。
Circulating estrogens are an established risk factor for breast cancer and some data suggested that diet may influence estrogen levels. Therefore, using a subsample (n=550) of women from a large cohort, we applied reduced rank regression to identify a dietary pattern that is correlated with estradiol and estrone sulfate. We then adapted the pattern to be used with the full cohort (n=67,802) and prospectively assessed its association with postmenopausal breast cancer. The estrogen food pattern, characterized by higher intakes of red meat, legumes, and pizza, but lower intakes of coffee and whole grains, was modestly but significantly correlated with estradiol (r=0.14) and estrone sulfate (r=0.20). During 22 years of follow-up, we ascertained 4,596 incident breast cancer, with 2,938 estrogen receptor positive tumors and 689 estrogen receptor negative tumors. However, after adjusting for potential confounders, we did not observe any association with overall, estrogen receptor positive, or estrogen receptor negative breast cancer. In conclusion, diet pattern appeared to only have modest association with estrogens, and was not associated to postmenopausal breast cancer risk. Although these results were null, it should be repeated in other populations as differences in food intake may yield a dietary pattern with stronger association with estrogens.
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影响因子：
5
作者：
Hoffmann, K;Schulze, MB;Boeing, H
通讯作者：
Boeing, H
影响因子：
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