The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007.
The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007.
复制标题
DOI：
10.1007/s10561-008-9067-2
复制
发表时间：
2008-09
影响因子：
1.5
通讯作者：
Rogers, Joseph
中科院分区：
文献类型：
--
作者：
Beach, Thomas G.;Sue, Lucia I.;Walker, Douglas G.;Roher, Alex E.;Lue, LihFen;Vedders, Linda;Connor, Donald J.;Sabbagh, Marwan N.;Rogers, Joseph
关键词：
Sun Health研究所的大脑捐赠计划自1987年以来一直在持续运营，已储存了1000多个大脑。研究的人口主要居住在亚利桑那州凤凰城西北部的退休社区。该研究所隶属于Sun Health，这是一家非营利性社区拥有和经营的医疗保健提供商。受试者前瞻性入组，以允许在生命期间进行标准化临床评估。资金主要来自竞争性赠款。该计划已作出短期死后大脑检索的优先事项，与2.75小时的中位数死后间隔为整个集合。这最大限度地提高了分子研究资源的效用;大约82%的病例的冷冻组织适合RNA研究。内部进行的研究表明，即使在非常短的死后间隔，大脑检索的延迟增加对RNA的完整性产生不利影响，脑脊液pH值随死后间隔增加，但不能预测组织活力。
The Brain Donation Program at Sun Health Research Institute has been in continual operation since 1987, with over 1000 brains banked. The population studied primarily resides in the retirement communities of northwest metropolitan Phoenix, Arizona. The Institute is affiliated with Sun Health, a nonprofit community-owned and operated health care provider. Subjects are enrolled prospectively to allow standardized clinical assessments during life. Funding comes primarily from competitive grants. The Program has made short postmortem brain retrieval a priority, with a 2.75-h median postmortem interval for the entire collection. This maximizes the utility of the resource for molecular studies; frozen tissue from approximately 82% of all cases is suitable for RNA studies. Studies performed in-house have shown that, even with very short postmortem intervals, increasing delays in brain retrieval adversely affect RNA integrity and that cerebrospinal fluid pH increases with postmortem interval but does not predict tissue viability.
登录
查看更多内容
影响因子：
3.3
作者：
HARDY, JA;WESTER, P;ERIKSSON, A
通讯作者：
ERIKSSON, A
DOI：
10.1097/nen.0b013e31802c3e7d
发表时间：
2007-01-01
影响因子：
3.2
作者：
Ferrer, Isidre;Santpere, Gabriel;Kretzschmar, Hans
通讯作者：
Kretzschmar, Hans
DOI：
10.1016/j.molbrainres.2005.04.017
发表时间：
2005-08-18
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
Catts, VS;Catts, SV;Lutze-Mann, LH
通讯作者：
Lutze-Mann, LH
DOI：
10.1006/bbrc.1998.9652
发表时间：
1998-11-27
影响因子：
3.1
作者：
Kuo, YM;Emmerling, MR;Roher, AE
通讯作者：
Roher, AE
影响因子：
4.2
作者：
Gärtner, U;Janke, C;Arendt, T
通讯作者：
Arendt, T