fMRI correlates of white matter hyperintensities in late-life depression.
fMRI correlates of white matter hyperintensities in late-life depression.
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DOI：
10.1176/appi.ajp.2011.10060853
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Reynolds CF 3rd
中科院分区：
文献类型：
--
作者：
Aizenstein HJ;Andreescu C;Edelman KL;Cochran JL;Price J;Butters MA;Karp J;Patel M;Reynolds CF 3rd
本研究测试是否结构性白色物质病变的特点是晚年抑郁症与改变功能性情感回路的晚年抑郁症。这项研究使用了一种情绪化的面孔范式，这种范式已经被证明可以激活大脑边缘系统的情感区域。33名老年抑郁症患者和27名非抑郁症对照受试者参加了这项研究。这些患者是通过NIMH赞助的匹兹堡大学生物伦理学和健康法中心的晚期情绪障碍研究干预和服务研究高级中心招募的。结构和功能磁共振成像被用来评估白色高信号（WMH）负荷和功能磁共振成像（fMRI）的血氧水平依赖（BOLD）反应的面部表情情感反应任务的老年参与者与非精神病和非双相型抑郁症（未用药）和非抑郁症老年对照组。正如所料，更大的膝下扣带回活动，观察抑郁症患者相对于非抑郁症的比较科目。抑郁组的脑血管白色物质变化的负荷更大，同一区域也表现出更大的任务相关活动。此外，抑郁组表现出更大的相互作用的WMH的fMRI活动效应比非抑郁组。老年抑郁症患者的高WMH负荷与情感反应性任务中更大的BOLD反应相关，这一观察结果支持了老年抑郁症患者的白色脑缺血破坏情感调节的脑机制并导致边缘系统过度激活的模型。
This study tests whether or not the structural white matter lesions that are characteristic of late-life depression are associated with alterations in the functional affective circuits of late-life depression. This study used an emotional faces paradigm that has been shown to engage the affective limbic brain regions. Thirty-three elderly depressed patients and 27 nondepressed comparison subjects participated in this study. The patients were recruited through the NIMH-sponsored Advanced Center for Interventions and Services Research for the Study of Late-Life Mood Disorders at the University of Pittsburgh Center for Bioethics and Health Law. Structural and functional MRI was used to assess white matter hyperintensity (WMH) burden and functional magnetic resonance imaging (fMRI) blood-oxygen-level-dependent (BOLD) response on a facial expression affective-reactivity task in both elderly participants with nonpsychotic and non-bipolar major depression (unmedicated) and nondepressed elderly comparison subjects. As expected, greater subgenual cingulate activity was observed in the depressed patients relative to the nondepressed comparison subjects. This same region showed greater task-related activity associated with a greater burden of cerebrovascular white matter change in the depressed group. Moreover, the depressed group showed a significantly greater interaction of WMH by fMRI activity effect than the nondepressed group. The observation that high WMH burden in late-life depression is associated with greater BOLD response on the affective-reactivity task supports the model that white matter ischemia in elderly depressed patients disrupts brain mechanisms of affective regulation and leads to limbic hyperactivation.
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影响因子：
7.2
作者：
Aizenstein, Howard J.;Butters, Meryl A.;Wu, Minjie;Mazurkewicz, Laura M.;Stenger, V. Andrew;Gianaros, Peter J.;Becker, James T.;Reynolds, Cbarles F., III;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
影响因子：
10.6
作者：
Drevets, WC
通讯作者：
Drevets, WC
影响因子：
5.7
作者：
Hariri, AR;Tessitore, A;Weinberger, DR
通讯作者：
Weinberger, DR
DOI：
10.1007/bf02191522
发表时间：
1993-07-01
影响因子：
4.7
作者：
KRISHNAN, KRR;MCDONALD, WM;ELLINWOOD, EH
通讯作者：
ELLINWOOD, EH
影响因子：
8.3
作者：
DeCarli, C;Fletcher, E;Jagust, WJ
通讯作者：
Jagust, WJ