Laser stimulation of single auditory nerve fibers.
Laser stimulation of single auditory nerve fibers.
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DOI：
10.1002/lary.21102
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发表时间：
2010-10
期刊：
影响因子：
2.6
通讯作者：
Richter, Claus-Peter
中科院分区：
文献类型：
--
作者：
Littlefield, Philip D.;Vujanovic, Irena;Mundi, Jagmeet;Matic, Agnella Izzo;Richter, Claus-Peter
耳蜗植入的一个限制是由于电极相互作用而难以刺激空间离散的螺旋神经节细胞群。多极电极对此有所改进，但也以更高的设备功耗为代价。最近，它已被证明，空间选择性刺激的听觉神经是可能的中红外激光瞄准螺旋神经节通过圆窗。然而，这些神经元必须以足够的速率驱动，以使光学辐射在耳蜗植入中有用。我们在此使用单纤维记录来表征听觉神经元对光辐射的反应。使用正常听力成年沙鼠的体内研究。两个二极管激光器用于刺激听神经。它们在1.844 μm和1.873 μm之间工作，脉冲持续时间为35 μs到1，000 μs，重复频率高达每秒1，000个脉冲（pps）。将激光输出耦合到一根直径为200 μ m的光纤上，光纤放置在圆窗膜上，并朝向螺旋神经节。通过开颅术暴露听神经，并在声学和激光刺激期间从单纤维进行记录。动作电位出现在激光脉冲后2.5 ~ 4.0ms。潜伏期抖动达3 ms，最大放电速率平均为每秒97 ± 52.5个动作电位。当刺激速率超过100 pps时，神经元对激光没有严格反应。听觉神经元可以被穿过圆窗膜的激光束刺激，并以足以获得有用听觉信息的速率驱动。光刺激和电刺激具有不同的特性，可以在未来的人工耳蜗植入中选择性地利用。不适用因
One limitation with cochlear implants is the difficulty stimulating spatially discrete spiral ganglion cell groups because of electrode interactions. Multipolar electrodes have improved on this some, but also at the cost of much higher device power consumption. Recently, it has been shown that spatially selective stimulation of the auditory nerve is possible with a mid-infrared laser aimed at the spiral ganglion via the round window. However, these neurons must be driven at adequate rates for optical radiation to be useful in cochlear implants. We herein use single-fiber recordings to characterize the responses of auditory neurons to optical radiation. In vivo study using normal-hearing adult gerbils. Two diode lasers were used for stimulation of the auditory nerve. They operated between 1.844 μm and 1.873 μm, with pulse durations of 35 μs to 1,000 μs, and at repetition rates up to 1,000 pulses per second (pps). The laser outputs were coupled to a 200-μm-diameter optical fiber placed against the round window membrane and oriented toward the spiral ganglion. The auditory nerve was exposed through a craniotomy, and recordings were taken from single fibers during acoustic and laser stimulation. Action potentials occurred 2.5 ms to 4.0 ms after the laser pulse. The latency jitter was up to 3 ms. Maximum rates of discharge averaged 97 ± 52.5 action potentials per second. The neurons did not strictly respond to the laser at stimulation rates over 100 pps. Auditory neurons can be stimulated by a laser beam passing through the round window membrane and driven at rates sufficient for useful auditory information. Optical stimulation and electrical stimulation have different characteristics; which could be selectively exploited in future cochlear implants. Not applicable.
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DOI：
10.1007/s10162-007-0108-5
发表时间：
2008-03-01
影响因子：
2.4
作者：
Miller, Charles A.;Hu, Ning;Abbas, Paul J.
通讯作者：
Abbas, Paul J.
DOI：
10.1007/s10162-003-3057-7
发表时间：
2004-03-01
影响因子：
2.4
作者：
Bierer, JA;Middlebrooks, JC
通讯作者：
Middlebrooks, JC
影响因子：
2.8
作者：
HARTMANN, R;TOPP, G;KLINKE, R
通讯作者：
KLINKE, R
影响因子：
2.8
作者：
Kral, A;Hartmann, R;Klinke, R
通讯作者：
Klinke, R
影响因子：
2.8
作者：
Javel, E;Shepherd, RK
通讯作者：
Shepherd, RK