Visiomode: An open-source platform for building rodent touchscreen-based behavioral assays.
Visiomode: An open-source platform for building rodent touchscreen-based behavioral assays.
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DOI：
10.1016/j.jneumeth.2022.109779
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发表时间：
2023-02-15
影响因子：
3
通讯作者：
Duguid, Ian
中科院分区：
文献类型：
--
作者：
Eleftheriou, Constantinos;Clarke, Thomas;Poon, V.;Zechner, Marie;Duguid, Ian
基于触摸屏的行为分析为评估啮齿动物的认知行为提供了一种可靠的方法，提供了极大的灵活性和翻译潜力。触摸屏检测的发展带来了巨大的编程和机械工程挑战，商业解决方案可能贵得令人望而却步，而开源解决方案开发不足，适应性有限。在这里，我们介绍了Visiomode(www.visiomode.org)，这是一个用于构建基于啮齿动物触摸屏的行为任务的开源平台。Visiomode利用触摸屏固有的灵活性来提供简单但适应性强的软件和硬件平台。该平台建立在Raspberry Pi计算机上，结合了基于网络的界面和功能强大的插件系统，以及可用于生成各种行为任务的操作室。作为概念的证明，我们使用Visiomode构建了简单的刺激反应和更复杂的视觉辨别任务，表明小鼠表现出快速的感觉-运动学习，包括在不同的运动反应之间切换(即，戳鼻子和伸展)。商业解决方案是啮齿动物触摸屏行为的首选，但相关成本可能令人望而却步，限制了更广泛的神经科学界对其的接受。虽然已经开发了几个开源解决方案，但到目前为止，努力的重点是降低成本，而不是促进易用性和适应性。Visiomode解决了这些未得到满足的需求，为创建触摸屏任务提供了一个低成本、可扩展的平台。开发一个开源、可快速扩展和低成本的平台来构建基于触摸屏的行为分析应该会增加科学界的接受，并加快对健康和疾病中的认知、决策和感觉运动行为的调查。用于构建啮齿动物触摸屏行为任务的开源平台。结合了基于Web的界面和功能强大的USB插件系统。即插即用设计可实现触摸屏任务的快速适应性和可扩展性。基于触摸屏的新型2-AFC前肢到达啮齿动物的任务。
Touchscreen-based behavioral assays provide a robust method for assessing cognitive behavior in rodents, offering great flexibility and translational potential. The development of touchscreen assays presents a significant programming and mechanical engineering challenge, where commercial solutions can be prohibitively expensive and open-source solutions are underdeveloped, with limited adaptability. Here, we present Visiomode (www.visiomode.org), an open-source platform for building rodent touchscreen-based behavioral tasks. Visiomode leverages the inherent flexibility of touchscreens to offer a simple yet adaptable software and hardware platform. The platform is built on the Raspberry Pi computer combining a web-based interface and powerful plug-in system with an operant chamber that can be adapted to generate a wide range of behavioral tasks. As a proof of concept, we use Visiomode to build both simple stimulus-response and more complex visual discrimination tasks, showing that mice display rapid sensorimotor learning including switching between different motor responses (i.e., nose poke versus reaching). Commercial solutions are the ‘go to’ for rodent touchscreen behaviors, but the associated costs can be prohibitive, limiting their uptake by the wider neuroscience community. While several open-source solutions have been developed, efforts so far have focused on reducing the cost, rather than promoting ease of use and adaptability. Visiomode addresses these unmet needs providing a low-cost, extensible platform for creating touchscreen tasks. Developing an open-source, rapidly scalable and low-cost platform for building touchscreen-based behavioral assays should increase uptake across the science community and accelerate the investigation of cognition, decision-making and sensorimotor behaviors both in health and disease. Open-source platform for building rodent touchscreen behavioral tasks. Combines a web-based interface and powerful USB plug-in system. Plug-and-play design enables rapid adaptability and scaling of touchscreen tasks. Novel touchscreen-based 2-AFC forelimb reaching task for rodents.
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