Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them.
Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them.
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DOI：
10.3390/antibiotics11020195
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发表时间：
2022-02-02
期刊：
影响因子：
--
通讯作者：
Vior NM
中科院分区：
文献类型：
--
作者：
Santos-Aberturas J;Vior NM
细菌次级代谢产物代表了制药和农业化学工业的生物活性分子的宝贵来源。虽然发现新化合物的筛选活动传统上一直强烈偏向于研究土壤中的放线菌，目前的抗生素耐药性和发现危机带来了相当大的关注，以前被忽视的细菌来源的次级代谢产物的研究。新的筛选、测序、遗传操作、培养和生物信息学技术的发展和应用揭示了其他几组细菌作为引人注目的化学新奇的生产者。生物合成机制从独立的分类学起源和完全不同的生态要求和选择压力下进化而来，负责这些结构创新。在这篇综述中，我们总结了与来自替代细菌来源的次级代谢物相关的最重要的发现，试图为读者提供一个广泛的视角，了解技术创新如何促进细菌代谢暗物质的获得。
Bacterial secondary metabolites represent an invaluable source of bioactive molecules for the pharmaceutical and agrochemical industries. Although screening campaigns for the discovery of new compounds have traditionally been strongly biased towards the study of soil-dwelling Actinobacteria, the current antibiotic resistance and discovery crisis has brought a considerable amount of attention to the study of previously neglected bacterial sources of secondary metabolites. The development and application of new screening, sequencing, genetic manipulation, cultivation and bioinformatic techniques have revealed several other groups of bacteria as producers of striking chemical novelty. Biosynthetic machineries evolved from independent taxonomic origins and under completely different ecological requirements and selective pressures are responsible for these structural innovations. In this review, we summarize the most important discoveries related to secondary metabolites from alternative bacterial sources, trying to provide the reader with a broad perspective on how technical novelties have facilitated the access to the bacterial metabolic dark matter.
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影响因子：
5.2
作者：
Alvarenga DO;Fiore MF;Varani AM
通讯作者：
Varani AM
DOI：
10.1002/chem.202003500
发表时间：
2020-12-04
期刊：
Chemistry (Weinheim an der Bergstrasse, Germany)
影响因子：
--
作者：
Neuwirth T;Letzel AC;Tank C;Ishida K;Cyrulies M;Schmölz L;Lorkowski S;Hertweck C
通讯作者：
Hertweck C
影响因子：
3.4
作者：
Bachmann, Brian O.;Van Lanen, Steven G.;Baltz, Richard H.
通讯作者：
Baltz, Richard H.
影响因子：
4.9
作者：
Baindara, Piyush;Chaudhry, Vasvi;Korpole, Suresh
通讯作者：
Korpole, Suresh
影响因子：
14.8
作者：
Agarwal V;Blanton JM;Podell S;Taton A;Schorn MA;Busch J;Lin Z;Schmidt EW;Jensen PR;Paul VJ;Biggs JS;Golden JW;Allen EE;Moore BS
通讯作者：
Moore BS