Drug repurposing in cancer neuroscience: From the viewpoint of the autophagy-mediated innervated niche.
Drug repurposing in cancer neuroscience: From the viewpoint of the autophagy-mediated innervated niche.
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DOI：
10.3389/fphar.2022.990665
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发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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基于神经科学与癌症科学之间的双向互动关系，提出了“癌症神经科学”这一新兴领域。神经和癌症之间的通信中的重要节点是神经支配的小生境，其与位于肿瘤附近的癌实质或神经具有物理接触。在神经支配的小生境中，自噬是一把双刃剑，在维持内环境稳定方面起着重要作用。因此，通过靶向自噬途径调节神经支配的小生境可能代表癌症治疗的新治疗策略。药物再利用因其成本效益和安全性的优势而受到广泛关注。因此，利用现有的药物，可能通过自噬途径调节神经支配的生态位是一种有前途的药理学方法，用于癌症神经科学的临床实践和治疗选择。在此，我们提出了癌症神经科学景观，重点是神经支配的小生境和自噬之间的串扰，同时也总结了候选药物在调节自噬途径的潜在机制。这篇综述从自噬介导的神经支配小生境的角度为癌症治疗中的药物再利用提供了强有力的理论基础。
Based on the bidirectional interactions between neurology and cancer science, the burgeoning field “cancer neuroscience” has been proposed. An important node in the communications between nerves and cancer is the innervated niche, which has physical contact with the cancer parenchyma or nerve located in the proximity of the tumor. In the innervated niche, autophagy has recently been reported to be a double-edged sword that plays a significant role in maintaining homeostasis. Therefore, regulating the innervated niche by targeting the autophagy pathway may represent a novel therapeutic strategy for cancer treatment. Drug repurposing has received considerable attention for its advantages in cost-effectiveness and safety. The utilization of existing drugs that potentially regulate the innervated niche via the autophagy pathway is therefore a promising pharmacological approach for clinical practice and treatment selection in cancer neuroscience. Herein, we present the cancer neuroscience landscape with an emphasis on the crosstalk between the innervated niche and autophagy, while also summarizing the underlying mechanisms of candidate drugs in modulating the autophagy pathway. This review provides a strong rationale for drug repurposing in cancer treatment from the viewpoint of the autophagy-mediated innervated niche.
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DOI：
10.1083/jcb.201401070
发表时间：
2014-09-01
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ashrafi G;Schlehe JS;LaVoie MJ;Schwarz TL
通讯作者：
Schwarz TL
DOI：
10.1038/s41579-018-0003-6
发表时间：
2018-06
期刊：
Nature reviews. Microbiology
影响因子：
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DOI：
10.1083/jcb.201412046
发表时间：
2015-05-11
期刊：
The Journal of cell biology
影响因子：
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作者：
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Sheng ZH
影响因子：
4.6
作者：
Brohée L;Peulen O;Nusgens B;Castronovo V;Thiry M;Colige AC;Deroanne CF
通讯作者：
Deroanne CF
影响因子：
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