Gene duplications and gene loss in the epidermal differentiation complex during the evolutionary land-to-water transition of cetaceans.
Gene duplications and gene loss in the epidermal differentiation complex during the evolutionary land-to-water transition of cetaceans.
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DOI：
10.1038/s41598-021-91863-3
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发表时间：
2021-06-10
影响因子：
4.6
通讯作者：
Eckhart L
中科院分区：
文献类型：
--
作者：
Holthaus KB;Lachner J;Ebner B;Tschachler E;Eckhart L
哺乳动物皮肤屏障的主要蛋白质组分由聚集在表皮分化复合物（EDC）中的基因编码。鲸目动物，即鲸、鼠海豚和海豚的皮肤在组织学上与陆地哺乳动物的皮肤不同。然而，其表皮屏障的遗传调节仅是不完全已知的。本文采用比较基因组学的方法对鲸类的EDC进行了研究。我们发现，重要的表皮角化蛋白，如兜甲蛋白和外皮蛋白是保守的和亚型的小脯氨酸丰富的蛋白质（SPRRs），甚至扩大在鲸类的数量。与此相反，角质细胞脯氨酸丰富蛋白（KPRP），皮肤特异性蛋白32（XP32）和晚期皮质包膜（LCE）基因与显着的例外LCE7A已经失去了鲸类。编码富含脯氨酸9（PRR9）和晚皮质样富含脯氨酸1（LELP 1）的基因在鲸类亚群中已经退化。这些数据表明，水生生活方式的演变是伴随着SPRR基因的扩增和特定的其他表皮分化基因的系统发育谱系导致鲸类动物的损失。
Major protein components of the mammalian skin barrier are encoded by genes clustered in the Epidermal Differentiation Complex (EDC). The skin of cetaceans, i.e. whales, porpoises and dolphins, differs histologically from that of terrestrial mammals. However, the genetic regulation of their epidermal barrier is only incompletely known. Here, we investigated the EDC of cetaceans by comparative genomics. We found that important epidermal cornification proteins, such as loricrin and involucrin are conserved and subtypes of small proline-rich proteins (SPRRs) are even expanded in numbers in cetaceans. By contrast, keratinocyte proline rich protein (KPRP), skin-specific protein 32 (XP32) and late-cornified envelope (LCE) genes with the notable exception of LCE7A have been lost in cetaceans. Genes encoding proline rich 9 (PRR9) and late cornified envelope like proline rich 1 (LELP1) have degenerated in subgroups of cetaceans. These data suggest that the evolution of an aquatic lifestyle was accompanied by amplification of SPRR genes and loss of specific other epidermal differentiation genes in the phylogenetic lineage leading to cetaceans.
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DOI：
10.1126/science.1252806
发表时间：
2014-06-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jiang Y;Xie M;Chen W;Talbot R;Maddox JF;Faraut T;Wu C;Muzny DM;Li Y;Zhang W;Stanton JA;Brauning R;Barris WC;Hourlier T;Aken BL;Searle SMJ;Adelson DL;Bian C;Cam GR;Chen Y;Cheng S;DeSilva U;Dixen K;Dong Y;Fan G;Franklin IR;Fu S;Guan R;Highland MA;Holder ME;Huang G;Ingham AB;Jhangiani SN;Kalra D;Kovar CL;Lee SL;Liu W;Liu X;Lu C;Lv T;Mathew T;McWilliam S;Menzies M;Pan S;Robelin D;Servin B;Townley D;Wang W;Wei B;White SN;Yang X;Ye C;Yue Y;Zeng P;Zhou Q;Hansen JB;Kristensen K;Gibbs RA;Flicek P;Warkup CC;Jones HE;Oddy VH;Nicholas FW;McEwan JC;Kijas J;Wang J;Worley KC;Archibald AL;Cockett N;Xu X;Wang W;Dalrymple BP
通讯作者：
Dalrymple BP
影响因子：
4.4
作者：
Aho, H;Schwemmer, M;Adham, IM
通讯作者：
Adham, IM
影响因子：
14.9
作者：
CORPET, F
通讯作者：
CORPET, F
影响因子：
10.3
作者：
de Koning, H. D.;van den Bogaard, E. H.;Zeeuwen, P. L. J. M.
通讯作者：
Zeeuwen, P. L. J. M.
影响因子：
6.5
作者：
Jackson, B;Tilli, CMLJ;Byrne, C
通讯作者：
Byrne, C