Intergenerational transmission of paternal trauma among US Civil War ex-POWs.
Intergenerational transmission of paternal trauma among US Civil War ex-POWs.
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DOI：
10.1073/pnas.1803630115
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发表时间：
2018-10-30
影响因子：
11.1
通讯作者：
DeSomer H
中科院分区：
文献类型：
--
作者：
Costa DL;Yetter N;DeSomer H
了解父亲的创伤是否会传播给儿童以影响他们的寿命，任何传播背后的机制以及父亲创伤的可逆性可以为健康干预提供信息，并增加我们对家庭健康持续性的理解。我们表明，作为战俘（POW）的父亲的严重困难导致高死亡率的儿子，但不是女儿，出生在战后谁存活到45岁，但足够的母亲营养对抗的影响，父亲的战俘创伤的方式最符合表观遗传学的解释。我们不知道任何大样本的研究，在人群中，检查父亲的创伤的可逆性，也没有父亲的长期影响，前战俘地位的儿童。我们研究了父亲的创伤是否会在美国内战（1861-1865年）期间传播给邦联战俘营（POW）幸存者的子女，以影响他们在老年时的寿命，这种传播背后的机制以及这种传播的可逆性。我们研究了战后出生的幸存到45岁的儿童，比较了父亲是非战俘退伍军人的儿童和被关押在非常不同的营地条件下的前战俘。我们还比较了战争前后出生的孩子在同一个家庭的父亲前战俘地位。在战俘营条件最差的时候被关押的前战俘的儿子的死亡率是非战俘的儿子的1.11倍，是战俘营条件较好的时候被关押的前战俘的儿子的1.09倍。父亲的前战俘身份对女儿没有影响。在第四季度出生的儿子中，当母亲在子宫内营养充足时，父亲的前战俘身份没有影响。相反，在母亲营养不足的第二季度出生的儿子中，经历过严重困难的前战俘的儿子的死亡率是非战俘和在囚禁中表现较好的前战俘的儿子的1.2倍。社会经济影响，家庭结构，父亲特有的生存特征，和母亲的影响，包括父亲的婚姻质量，不能解释我们的研究结果。虽然我们不能完全排除心理或文化影响，但我们的发现与表观遗传学的解释最为一致。
Understanding whether paternal trauma is transmitted to children to affect their longevity, the mechanisms behind any transmission, and the reversibility of paternal trauma can inform health interventions and increase our understanding of the persistence of health within families. We show that severe paternal hardship as a prisoner of war (POW) led to high mortality among sons, but not daughters, born after the war who survived to the age of 45 but that adequate maternal nutrition countered the effect of paternal POW trauma in a manner most consistent with epigenetic explanations. We are not aware of any large sample studies in human populations that examine the reversibility of paternal trauma nor the long-term impact of paternal ex-POW status on children. We study whether paternal trauma is transmitted to the children of survivors of Confederate prisoner of war (POW) camps during the US Civil War (1861–1865) to affect their longevity at older ages, the mechanisms behind this transmission, and the reversibility of this transmission. We examine children born after the war who survived to age 45, comparing children whose fathers were non-POW veterans and ex-POWs imprisoned in very different camp conditions. We also compare children born before and after the war within the same family by paternal ex-POW status. The sons of ex-POWs imprisoned when camp conditions were at their worst were 1.11 times more likely to die than the sons of non-POWs and 1.09 times more likely to die than the sons of ex-POWs when camp conditions were better. Paternal ex-POW status had no impact on daughters. Among sons born in the fourth quarter, when maternal in utero nutrition was adequate, there was no impact of paternal ex-POW status. In contrast, among sons born in the second quarter, when maternal nutrition was inadequate, the sons of ex-POWs who experienced severe hardship were 1.2 times more likely to die than the sons of non-POWs and ex-POWs who fared better in captivity. Socioeconomic effects, family structure, father-specific survival traits, and maternal effects, including quality of paternal marriages, cannot explain our findings. While we cannot rule out fully psychological or cultural effects, our findings are most consistent with an epigenetic explanation.
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影响因子：
3.3
作者：
Class QA;Lichtenstein P;Långström N;D'Onofrio BM
通讯作者：
D'Onofrio BM
影响因子：
25
作者：
Gapp, Katharina;Jawaid, Ali;Sarkies, Peter;Bohacek, Johannes;Pelczar, Pawel;Prados, Julien;Farinelli, Laurent;Miska, Eric;Mansuy, Isabelle M.
通讯作者：
Mansuy, Isabelle M.
影响因子：
3.3
作者：
Dekel, Rachel;Goldblatt, Hadass
通讯作者：
Goldblatt, Hadass
影响因子：
5.4
作者：
Ekamper, P.;van Poppel, F.;Lumey, L. H.
通讯作者：
Lumey, L. H.
DOI：
10.1073/pnas.0703739104
发表时间：
2007-08-07
影响因子：
11.1
作者：
Dolinoy, Dana C.;Huang, Dale;Jirtle, Randy L.
通讯作者：
Jirtle, Randy L.