Demographic, clinical, and biochemical predictors of pica in a large cohort of blood donors.
Demographic, clinical, and biochemical predictors of pica in a large cohort of blood donors.
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DOI：
10.1111/trf.16409
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发表时间：
2021-07
期刊：
影响因子：
2.9
通讯作者：
NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III
中科院分区：
文献类型：
--
作者：
Liu H;Burns RT;Spencer BR;Page GP;Mast AE;NHLBI Recipient Epidemiology Donor Evaluation Study (REDS)-III
异食癖的特征是反复吃或咀嚼非营养物质，包括但不限于冰、粘土和泥土、淀粉、生意大利面、粉笔、煤、油漆或纸。异食癖症状可能很严重，类似成瘾，会破坏生活质量。它与缺铁密切相关。由于献血过程中会发生大量铁损失，献血者可能容易出现异食癖行为。我们对 11,418 名不同种族的献血者进行单变量和多变量逻辑回归分析，研究了与异食癖相关的人口统计学、临床、血液学和生化因素。根据调查问卷的回答，异食癖被定义为每天至少消耗 8 盎司冰和/或消耗非冰物质，无论数量和频率如何。 2.2% 的捐赠者存在异食癖。缺铁供体中异食癖的敏感性和特异性分别为 36% 和 82%。铁蛋白较低 (p = .001)、非亚洲人种 (p < .001)、红细胞分布宽度较高 (p < .001)、年龄较小和不宁腿综合征 (p = .008) 与异食癖独立相关。女性与缺铁有关，但并不是异食癖的独立预测因素，这表明缺铁的男性和女性同样容易出现异食癖行为。铁蛋白水平正常的捐献者也报告了异食癖，这强化了非铁相关因素在其表现中的作用。我们已经确定了异食癖的人口统计学、临床和生化预测因素，有助于识别那些最有可能发生异食癖行为的人，从而协助其临床诊断和治疗。
Pica is characterized as repeatedly eating or chewing a non-nutritious substance including, but not limited to ice, clay and dirt, starch, raw pasta, chalk, coal, paint, or paper. Pica symptoms can be intense and addiction-like and disrupt quality of life. It is strongly linked to iron deficiency. Since substantial iron loss occurs during blood donation, blood donors may be susceptible to development of pica behaviors. We investigated demographic, clinical, hematological, and biochemical factors associated with pica using univariable and multivariable logistic regression analysis in a cohort of 11,418 racially diverse blood donors. Pica was defined by questionnaire responses as consuming at least 8 oz of ice daily and/or consumption of non-ice substances regardless of the amount and frequency. Pica was present in 2.2% of the donors. The sensitivity and specificity of pica in iron-deficient donors were 36% and 82%, respectively. Lower ferritin (p = .001), non-Asian race (p < .001), higher red cell distribution width (p < .001), younger age, and restless legs syndrome (p = .008) were independently associated with pica. Female sex is associated with iron deficiency but was not an independent predictor of pica suggesting that iron deficient males and females were equally susceptible to the development of pica behaviors. Donors with normal ferritin levels also reported pica, reinforcing the role of non-iron related factors in its presentation. We have identified demographic, clinical, and biochemical predictors of pica that help identify those most at risk for developing pica behaviors, and thereby assist in its clinical diagnosis and treatment.
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