Optical Microangiography and Progressive Retinal Nerve Fiber Layer Loss in Primary Open Angle Glaucoma.
Optical Microangiography and Progressive Retinal Nerve Fiber Layer Loss in Primary Open Angle Glaucoma.
复制标题
原发性开角型青光眼的光学微血管造影与进行性视网膜神经纤维层丢失
DOI：
10.1016/j.ajo.2021.07.023
复制
发表时间：
2022-01
影响因子：
4.2
通讯作者：
Weinreb RN
中科院分区：
文献类型：
--
作者：
Rao HL;Dasari S;Puttaiah NK;Pradhan ZS;Moghimi S;Mansouri K;Webers CAB;Weinreb RN
目的探讨原发性开角型青光眼(POAG)视网膜神经纤维层(RNFL)丢失与光学微血管造影(OMAG)测量的关系。前瞻性病例系列对40例(108象限)轻中度功能损害的POAG患者的64只眼进行了至少2年的纵向研究，并至少进行了3次光学相干断层扫描(OCT)检查。在基线访问时进行OMAG成像。用线性混合模型评价临床参数(年龄、性别、有无全身性疾病、中央角膜厚度、视盘出血、平均眼压和眼压波动)、基线半视野平均偏差(MD)、基线象限OCT(视网膜神经纤维层[RNFL]和神经节细胞内丛状层[GCIPL]厚度)和OMAG(乳头和黄斑周围血流密度[PD]和血管密度[VD])对RNFL改变率的影响。基线分析象限的平均(±SD)MD、RNFL和GCIPL厚度分别为−5.5±2.9分贝、96.5±17.9μm和73.8±8.6μm。乳头区Pd和Vd分别为44.6±5.9%和17.5±2.2 mm/mm2。象限RNFL变化率为−1.8±0.6μm/年。多因素混合模型显示，较低的乳头周围PD(系数：0.08，p=0.01)和较低的VD(系数：0.21，p=0.02)与较快的RNFL丢失率显著相关。OMAG测量的低基线乳头周围PD和Vd与POAG患者较快的RNFL丢失率显著相关。OMAG成像提供了有关青光眼进展风险和疾病恶化速度的有用信息。在平均3年的随访期内，光学微血管造影术测量的较低的乳头周围血流密度(系数：0.08，p=0.01)和较低的乳头周围血管密度(系数：0.21，p=0.02)与视网膜神经纤维层变薄的速度显著相关。
To evaluate the association between optical microangiography (OMAG) measurements and progressive retinal nerve fiber layer (RNFL) loss in primary open angle glaucoma (POAG). Prospective case series Sixty-four eyes of 40 POAG patients (108 quadrants) with mild to moderate functional damage were longitudinally studied for at least 2 years and with a minimum of 3 optical coherence tomography (OCT) examinations. OMAG imaging was performed at the baseline visit. Effect of clinical parameters (age, gender, presence of systemic diseases, central corneal thickness, presence of disc hemorrhage, mean and fluctuation of intraocular pressure during follow-up), baseline hemifield mean deviation (MD), baseline quadrant OCT (retinal nerve fiber layer [RNFL] and ganglion cell inner plexiform layer [GCIPL] thickness) and OMAG (peripapillary and macular perfusion density [PD] and vessel density [VD]) on the rate of RNFL change was evaluated using linear mixed models. Average (±SD) MD, RNFL and GCIPL thickness of the analyzed quadrants at baseline were −5.5±2.9 dB, 96.5±17.9 μm, and 73.8±8.6 μm, respectively. Peripapillary PD and VD in the quadrant were 44.6±5.9% and 17.5±2.2 mm/mm2 respectively. Rate of quadrant RNFL change was −1.8±0.6 μm/year. Multivariate mixed models showed that lower peripapillary PD (coefficient: 0.08, p=0.01) and lower VD (coefficient: 0.21, p=0.02) were significantly associated with faster rate of RNFL loss. Lower baseline peripapillary PD and VD measured using OMAG were significantly associated with a faster rate of RNFL loss in POAG. OMAG imaging provides useful information about the risk of glaucoma progression and the rate of disease worsening. Lower peripapillary perfusion density (coefficient: 0.08, p=0.01) and lower peripapillary vessel density (coefficient: 0.21, p=0.02) measured at baseline using optical microangiography were significantly associated with faster rate of retinal nerve fiber layer thinning in primary open angle glaucoma eyes over a mean follow-up of 3 years.
登录
查看更多内容
影响因子：
13.7
作者：
Jia Y;Wei E;Wang X;Zhang X;Morrison JC;Parikh M;Lombardi LH;Gattey DM;Armour RL;Edmunds B;Kraus MF;Fujimoto JG;Huang D
通讯作者：
Huang D
影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
--
作者：
De Moraes, Carlos Gustavo V.;Juthani, Viral J.;Ritch, Robert
通讯作者：
Ritch, Robert
影响因子：
2.3
作者：
Laird, N M;Donnelly, C;Ware, J H
通讯作者：
Ware, J H
影响因子：
13.7
作者：
Diniz-Filho A;Abe RY;Zangwill LM;Gracitelli CP;Weinreb RN;Girkin CA;Liebmann JM;Medeiros FA
通讯作者：
Medeiros FA