Activation of p38 mitogen-activated protein kinase module facilitates in vitro host cell invasion by Rickettsia rickettsii.
Activation of p38 mitogen-activated protein kinase module facilitates in vitro host cell invasion by Rickettsia rickettsii.
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p38 丝裂原激活蛋白激酶模块的激活促进立克次体体外入侵宿主细胞。
DOI：
10.1099/jmm.0.47806-0
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发表时间：
2008
影响因子：
3
通讯作者：
Sahni,SanjeevK
中科院分区：
文献类型：
--
作者：
Rydkina,Elena;Turpin,LoelC;Sahni,SanjeevK
Interactions with target membrane molecules and the resultant internalization into host cells are, in general, the first and foremost steps for subsequent host responses and pathogenesis of infectious micro-organisms. For pathogenic bacteria belonging to both spotted fever and typhus subgroups of Rickettsia species, which are known for dependence on the nutrientrich environment of the host cytoplasm and fastidious growth requirements, target cell invasion is absolutely critical for subsequent intracellular replication and intercellular spread. Rickettsia rickettsii, the causative agent of Rocky Mountain spotted fever, primarily affects the endothelial cell lining of small-and medium-sized vessels leading to disseminated intracellular infection of the vasculature and, consequently, characteristic pathological features during human infections correspond to vascular inflammation, damage and dysfunction (Walker, 2007).Initial studies using Rickettsia prowazekii, the aetiological agent of epidemic typhus, revealed that inactivation of bacteria or alterations in the host cell cytoskeleton adversely affect rickettsial uptake into cultured human umbilical vein-derived endothelial cells, suggesting that the viability of both the host cell and adherent rickettsiae is an essential prerequisite for successful invasion via ‘induced phagocytosis’(Walker, 1984). Subsequent investigations by electron microscopy further indicated that rickettsial entry into Vero cells is almost instantaneous (occurring within 3 min of bacterium–host cell contact) and rickettsiae are able to quickly escape from the phagosome into the cytoplasm, presumably prior to phagolysosomal fusion (Teysseire et al., 1995), and likely via a phospholipase activity (Whitworth et al., 2005). An important role for host actin polymerization in rickettsial internalization of non-phagocytic cells has also been suggested. Analysis of proteins known to govern actin dynamics has
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立克次体人内皮细胞胞浆提取物中核因子 κB 的蛋白酶体依赖性激活
影响因子：
3.1
作者：
S. Sahni;D. V. Van Antwerp;M. Eremeeva;D. Silverman;V. Marder;L. Sporn
通讯作者：
L. Sporn
影响因子：
3.4
作者：
Coombes, BK;Mahony, JB
通讯作者：
Mahony, JB
康氏立克次体进入Vero细胞
影响因子：
3.1
作者：
N. Teysseire;J. Boudier;D. Raoult
通讯作者：
D. Raoult
康氏立克次体和伤寒立克次体感染激活的宿主细胞信号传导机制的比较分析。
影响因子：
3
作者：
Rydkina,Elena;Sahni,Abha;Silverman,DavidJ;Sahni,SanjeevK
通讯作者：
Sahni,SanjeevK
影响因子：
4
作者：
Martinez, JJ;Cossart, P
通讯作者：
Cossart, P