Choice selective inhibition drives stability and competition in decision circuits.
Choice selective inhibition drives stability and competition in decision circuits.
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DOI：
10.1038/s41467-023-35822-8
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发表时间：
2023-01-10
影响因子：
16.6
通讯作者：
Engel, Tatiana A.
中科院分区：
文献类型：
--
作者：
Roach, James P.;Churchland, Anne K.;Engel, Tatiana A.
在知觉决策过程中，皮层神经元的放电率反映了即将到来的选择。最近的研究表明，兴奋性神经元和抑制性神经元对选择同样具有选择性。然而，决策回路中抑制选择选择性的功能后果尚不清楚。我们开发了一个决策电路模型，该模型解释了抑制性神经元输入和输出的特异性。我们发现选择性抑制扩大了支持决策的回路的空间，当连接到竞争或反馈基序时，允许更弱或更强的循环激励。抑制输出的特异性通过稳定或破坏电路中决策基础的鞍点动态来设定决策的速度和准确性之间的权衡。经过训练来做决定的循环神经网络对抑制特异性和循环兴奋的强度表现出同样的依赖性。我们的研究结果揭示了选择抑制在决策回路中的两个并行作用：稳定强连接的兴奋性种群和最大化相反选择种群之间的竞争。在决策回路中，抑制性神经元发出动物选择的信号。在这里，作者表明选择选择性抑制可以通过抑制输出连接来稳定电路动态或促进竞争，从而影响选择行为。
During perceptual decision-making, the firing rates of cortical neurons reflect upcoming choices. Recent work showed that excitatory and inhibitory neurons are equally selective for choice. However, the functional consequences of inhibitory choice selectivity in decision-making circuits are unknown. We developed a circuit model of decision-making which accounts for the specificity of inputs to and outputs from inhibitory neurons. We found that selective inhibition expands the space of circuits supporting decision-making, allowing for weaker or stronger recurrent excitation when connected in a competitive or feedback motif. The specificity of inhibitory outputs sets the trade-off between speed and accuracy of decisions by either stabilizing or destabilizing the saddle-point dynamics underlying decisions in the circuit. Recurrent neural networks trained to make decisions display the same dependence on inhibitory specificity and the strength of recurrent excitation. Our results reveal two concurrent roles for selective inhibition in decision-making circuits: stabilizing strongly connected excitatory populations and maximizing competition between oppositely selective populations. In decision circuits, inhibitory neurons signal animal choices. Here, the authors show that choice-selective inhibition can stabilize the circuit dynamics or promote competition depending on inhibitory output connections, affecting choice behavior.
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影响因子：
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影响因子：
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