Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation.
Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation.
复制标题
DOI：
10.1111/imr.12170
复制
发表时间：
2014-05
影响因子：
8.7
通讯作者：
Campbell DJ
中科院分区：
文献类型：
--
作者：
Smigiel KS;Srivastava S;Stolley JM;Campbell DJ
Regulatory T (Treg) cells play a vital role in the prevention of autoimmunity and the maintenance of self-tolerance but also have an active role in inhibiting immune responses during viral, bacterial and parasitic infections. Whereas excessive Treg activity can lead to immunodeficiency, chronic infection and cancer, too little Treg activity results in autoimmunity and immunopathology, and impairs the quality of pathogen-specific responses. Recent studies have helped define the homeostatic mechanisms that support the diverse pool of peripheral Treg cells under steady-state conditions, and delineate how the abundance and function of Treg cells changes during inflammation. These findings are highly relevant for developing effective strategies to manipulate Treg cell activity to promote allograft tolerance and treat autoimmunity, chronic infection and cancer.
登录
查看更多内容
影响因子：
2.6
作者：
Brusko, Todd;Atkinson, Mark
通讯作者：
Atkinson, Mark
DOI：
10.1084/jem.20130097
发表时间：
2013-07-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Ballesteros-Tato A;León B;Lund FE;Randall TD
通讯作者：
Randall TD
影响因子：
4.4
作者：
Burchill, Matthew A.;Yang, Jianying;Farrar, Michael A.
通讯作者：
Farrar, Michael A.
影响因子：
20.3
作者：
Carreras, Joaquim;Lopez-Guillermo, Armando;Banham, Alison H.
通讯作者：
Banham, Alison H.
T细胞和天然杀伤细胞的稳态维护。
影响因子：
8
作者：
Boyman, Onur;Krieg, Carsten;Homann, Dirk;Sprent, Jonathan
通讯作者：
Sprent, Jonathan