Biofilm matrix and its regulation in Pseudomonas aeruginosa.

Biofilm matrix and its regulation in Pseudomonas aeruginosa.
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铜绿假单胞菌生物膜基质及其调控

DOI:
10.3390/ijms141020983
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发表时间:
2013-10-18
影响因子:
5.6
通讯作者:
Ma LZ
Ma LZ
中科院分区:
生物学2区
文献类型:
--
作者:
Wei Q;Ma LZ

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生物膜是微生物在胞外聚合物(EPS)基质中的生物群落。生物膜中的细菌表现出与其自由生活的寄生虫对应物不同的特征,例如不同的生理学和对免疫系统和抗生素的高抗性,使得生物膜成为慢性和持续性感染的来源。对生物膜的更深入了解将最终为生物膜感染的替代治疗的发展提供见解。条件致病菌铜绿假单胞菌(Pseudomonasaeruginosa)是用于生物膜研究的模式细菌,因其通过涉及生物膜形成的高水平耐药性而引起慢性感染的能力而臭名昭著。本文综述了铜绿假单胞菌生物被膜形成的研究进展,重点介绍了铜绿假单胞菌生物被膜基质及其调控,旨在为了解和控制细菌生物被膜提供参考。
Biofilms are communities of microorganisms embedded in extracellular polymeric substances (EPS) matrix. Bacteria in biofilms demonstrate distinct features from their free-living planktonic counterparts, such as different physiology and high resistance to immune system and antibiotics that render biofilm a source of chronic and persistent infections. A deeper understanding of biofilms will ultimately provide insights into the development of alternative treatment for biofilm infections. The opportunistic pathogen Pseudomonas aeruginosa, a model bacterium for biofilm research, is notorious for its ability to cause chronic infections by its high level of drug resistance involving the formation of biofilms. In this review, we summarize recent advances in biofilm formation, focusing on the biofilm matrix and its regulation in P. aeruginosa, aiming to provide resources for the understanding and control of bacterial biofilms.
DOI: 10.1371/journal.pone.0014220
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