Urinary cortisol and depression in early pregnancy: role of adiposity and race.
Urinary cortisol and depression in early pregnancy: role of adiposity and race.
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DOI：
10.1186/s12884-015-0466-7
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发表时间：
2015-02-13
影响因子：
3.1
通讯作者：
Powers RW
中科院分区：
文献类型：
--
作者：
Luiza JW;Gallaher MJ;Powers RW
怀孕前和怀孕期间的抑郁症与不良的出生结果有关，包括低出生体重和早产。异常的母体皮质醇被假设为抑郁症和不良出生结果之间的一个中介。皮质醇与妊娠期抑郁症之间的关系在非裔美国人中表现得最为强烈，大多数研究都集中在循环或胎盘皮质醇水平上。尿皮质醇在妊娠早期与抑郁和肥胖相关的效用尚未研究。25个怀孕的非裔美国妇女确定的爱丁堡抑郁量表抑郁症进行了调查，并匹配的身体质量指数（BMI），年龄，种族，和婴儿出生体重百分位数的非抑郁症患者。母亲的尿液和血浆皮质醇在怀孕早期进行了量化和调查有关的抑郁症和肥胖症。晨尿皮质醇水平与血浆皮质醇呈正相关（r2 = 0.25，p < 0.001）。然而，抑郁和非抑郁孕妇之间的尿或血浆皮质醇没有观察到差异。血浆皮质醇与包括体脂百分比在内的几项母亲肥胖指标呈显著负相关（r2 =-0.10，p < 0.05），但这种关系仅存在于非抑郁症女性中。在事后分析中，发现非抑郁非肥胖女性的皮质醇水平显著高于抑郁、肥胖或两者兼而有之的女性（p < 0.05）。与非抑郁非肥胖孕妇相比，抑郁孕妇和非抑郁肥胖孕妇的皮质醇水平不典型。妊娠早期血浆皮质醇与孕产妇肥胖指标呈负相关。抑郁（瘦和肥胖）和非抑郁肥胖的非裔美国孕妇中非典型低循环母体皮质醇可能表明妊娠早期下丘脑-垂体轴功能障碍。
Depression before and during pregnancy is associated with adverse birth outcomes including low birth weight and preterm birth. Abnormal maternal cortisol has been hypothesized as one mediator between depression and adverse birth outcomes. The relationship between cortisol and depression in pregnancy is exhibited most strongly in the African American population, and most studies have focused either on circulating or placental levels of cortisol. The utility of urinary cortisol in early pregnancy related to depression and adiposity has not been investigated. Twenty-five pregnant African American women identified by the Edinburgh Depression Scale as having depression were investigated and matched by body mass index (BMI), age, race, and infant birth weight centile to non-depressed subjects. Maternal urine and plasma cortisol in early pregnancy were quantified and investigated in relation to depression and adiposity. Morning urine cortisol levels tracked positively with plasma cortisol (r2 = 0.25, p < 0.001). However, no differences were observed in either urinary or plasma cortisol between depressed and non-depressed pregnant women. Plasma cortisol was significantly negatively associated with several measures of maternal adiposity including percent body fat (r2 = −0.10, p < 0.05), however this relationship was present only in the non-depressed women. In a post-hoc analysis, non-depressed non-obese women were found to have significantly higher cortisol levels compared to women with depression, obesity or both (p < 0.05). Depressed pregnant women and non-depressed obese pregnant women evidence atypical cortisol levels compared to non-depressed non-obese pregnant women. Plasma cortisol in early pregnancy is negatively associated with measures of maternal adiposity. Atypical low circulating maternal cortisol among depressed (lean and obese) and non-depressed obese pregnant African American women may indicate hypothalamic-pituitary axis dysfunction in early pregnancy.
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影响因子：
--
作者：
Grote, Nancy K.;Bridge, Jeffrey A.;Gavin, Amelia R.;Melville, Jennifer L.;Iyengar, Satish;Katon, Wayne J.
通讯作者：
Katon, Wayne J.
影响因子：
4.7
作者：
Vianna, Priscila;Bauer, Moises E.;Bogo Chies, Jose Artur
通讯作者：
Bogo Chies, Jose Artur
影响因子：
6.9
作者：
Champaneri, Shivam;Xu, Xiaoqiang;Carnethon, Mercedes R.;Bertoni, Alain G.;Seeman, Teresa;DeSantis, Amy S.;Roux, Ana Diez;Shrager, Sandi;Golden, Sherita Hill
通讯作者：
Golden, Sherita Hill
影响因子：
3.6
作者：
Aufdenblatten, Myriam;Baumann, Marc;Mohaupt, Markus G.
通讯作者：
Mohaupt, Markus G.
影响因子：
3.3
作者：
Epel, ES;McEwen, B;Ickovics, JR
通讯作者：
Ickovics, JR