Cytokines associated with necrotizing enterocolitis in extremely-low-birth-weight infants.
Cytokines associated with necrotizing enterocolitis in extremely-low-birth-weight infants.
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DOI：
10.1038/pr.2014.48
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发表时间：
2014-07
影响因子：
3.6
通讯作者：
Higgins, Rosemary D.
中科院分区：
文献类型：
--
作者：
Maheshwari, Akhil;Schelonka, Robert L.;Dimmitt, Reed A.;Carlo, Waldemar A.;Munoz-Hernandez, Breda;Das, Abhik;McDonald, Scott A.;Thorsen, Poul;Skogstrand, Kristin;Hougaard, David M.;Higgins, Rosemary D.
目标是确定与坏死性小肠结肠炎 (NEC) 相关的细胞因子。根据我们早期关于转化生长因子 (TGF)-β 组织表达减少的报告，我们假设患有 NEC 的婴儿血液 TGF-β 水平也较低。我们进一步假设，由于胎儿炎症会增加 NEC 的风险，因此发生 NEC 的婴儿在新生儿早期血液细胞因子水平升高。对来自 17 个中心的 104 名患有 NEC 的极低出生体重 (ELBW) 婴儿和 893 名不患有 NEC 的婴儿的数据进行了分析。临床信息与出生后第 1 天 (D1)、D3、D7、D14 和 D21 的血液细胞因子水平相关。男性、非白种人/非非裔美国人、败血症、较低的血液 TGF-β 和白细胞介素 (IL)-2 水平以及较高的 IL-8 水平与 NEC 相关。自 D1 起，NEC 组的 TGF-β 水平低于对照组。 NEC 的诊断与 IL-1β、IL-6、IL-8、IL-10、单核细胞趋化蛋白-1/CC-基序配体 (CCL)-2、巨噬细胞炎症蛋白-1β/CCL3 和 C 反应蛋白升高相关。临床特征，例如性别和种族以及低血液 TGF-β 水平与较高的 NEC 风险相关。患 NEC 的婴儿一开始血液中炎症细胞因子的水平并不高，但这些细胞因子主要在 NEC 发病后升高。
The goal was to identify cytokines associated with necrotizing enterocolitis (NEC). Based on our earlier reports of decreased tissue expression of transforming growth factor (TGF)-β, we hypothesized that infants with NEC also have low blood TGF-β levels. We further hypothesized that because fetal inflammation increases the risk of NEC, infants who develop NEC have elevated blood cytokine levels in early neonatal period. Data on 104 extremely low birth weight (ELBW) infants with NEC and 893 without NEC from 17 centers were analyzed. Clinical information was correlated with blood cytokine levels on postnatal day 1 (D1), D3, D7, D14, and D21. Male gender, non-Caucasian/non-African-American ethnicity, sepsis, lower blood TGF-β and interleukin (IL)-2, and higher IL-8 levels were associated with NEC. The NEC group had lower TGF-β levels than controls since D1. The diagnosis of NEC was associated with elevated IL-1β, IL-6, IL-8, IL-10, monocyte chemoattractant protein-1/CC-motif ligand (CCL)-2, macrophage inflammatory protein-1β/CCL3, and C-reactive protein. Clinical characteristics, such as gender and ethnicity, and low blood TGF-β levels are associated with higher risk of NEC. Infants who developed NEC did not start with high blood levels of inflammatory cytokines, but these rose mainly after the onset of NEC.
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影响因子：
5.1
作者：
Carlo, Waldemar A.;McDonald, Scott A.;Tyson, Jon E.;Stoll, Barbara J.;Ehrenkranz, Richard A.;Shankaran, Seetha;Goldberg, Ronald N.;Das, Abhik;Schendel, Diana;Thorsen, Poul;Skogstrand, Kristin;Hougaard, David M.;Oh, William;Laptook, Abbot R.;Duara, Shahnaz;Fanaroff, Avroy A.;Donovan, Edward F.;Korones, Sheldon B.;Stevenson, David K.;Papile, Lu-Ann;Finer, Neil N.;O'Shea, T. Michael;Poindexter, Brenda B.;Wright, Linda L.;Ambalavanan, Namasivayam;Higgins, Rosemary D.
通讯作者：
Higgins, Rosemary D.
影响因子：
2.4
作者：
Edelson, MB;Sonnino, RE;Rozycki, HJ
通讯作者：
Rozycki, HJ
影响因子：
3.6
作者：
Maheshwari, A;Lacson, A;Calhoun, DA
通讯作者：
Calhoun, DA
DOI：
10.1007/s10024-002-0602-z
发表时间：
2003-01
期刊：
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
影响因子：
--
作者：
Hsueh W;Caplan MS;Qu XW;Tan XD;De Plaen IG;Gonzalez-Crussi F
通讯作者：
Gonzalez-Crussi F
影响因子：
1.8
作者：
Anttila, A;Kauppinen, H;Rintala, R
通讯作者：
Rintala, R