Sex, mating and repeatability of Drosophila melanogaster longevity.
Sex, mating and repeatability of Drosophila melanogaster longevity.
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果蝇Melanogaster寿命的性别，交配和可重复性。
DOI：
10.1098/rsos.210273
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发表时间：
2021-08
影响因子：
3.5
通讯作者：
Austad SN
中科院分区：
文献类型：
--
作者：
Hoffman JM;Dudeck SK;Patterson HK;Austad SN
繁殖成本似乎在动物王国中无处不在，这些繁殖成本通常被定义为繁殖增加导致其他健康成分（通常是寿命）减少。然而，最近的一些报告质疑是否每个物种或种群都存在生殖成本。为了提供对这个问题的见解，我们试图确定遗传变异在某种程度上可能发挥作用的一种类型的繁殖成本生存使用果蝇。令人惊讶的是，我们发现，在两个队列的所有15种遗传背景中，生殖成本和寿命都没有性别差异。我们确实在一些基因型中发现了显著的变异，尽管这些变异比预期的要小得多。我们还观察到，小的实验室变化导致基因型内寿命的显着变化，这表明在苍蝇寿命重复性可能是困难的。最后，我们将我们的结果与以前发表的寿命进行了比较，发现可重复性与我们在自己的实验室中看到的相似，进一步表明随机性是果蝇寿命的重要组成部分。总的来说，我们的研究结果表明，我们对性别和交配的影响，以及遗传背景和实验室条件对寿命重现性的影响的认识仍然存在很大的差距。
Costs of reproduction are seemingly ubiquitous across the animal kingdom, and these reproductive costs are generally defined by increased reproduction leading to decreases in other fitness components, often longevity. However, some recent reports question whether reproductive costs exist in every species or population. To provide insight on this issue, we sought to determine the extent to which genetic variation might play a role in one type of reproductive cost—survival—using Drosophila melanogaster. We found, surprisingly, no costs of reproduction nor sex differences in longevity across all 15 genetic backgrounds in two cohorts. We did find significant variation within some genotypes, though these were much smaller than expected. We also observed that small laboratory changes lead to significant changes in longevity within genotypes, suggesting that longevity repeatability in flies may be difficult. We finally compared our results to previously published longevities and found that reproducibility is similar to what we saw in our own laboratory, further suggesting that stochasticity is a strong component of fruit fly lifespan. Overall, our results suggest that there are still large gaps in our knowledge about the effects of sex and mating, as well as genetic background and laboratory conditions on lifespan reproducibility.
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影响因子：
7.8
作者：
Harrison DE;Strong R;Allison DB;Ames BN;Astle CM;Atamna H;Fernandez E;Flurkey K;Javors MA;Nadon NL;Nelson JF;Pletcher S;Simpkins JW;Smith D;Wilkinson JE;Miller RA
通讯作者：
Miller RA
影响因子：
64.8
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Burnett, Camilla;Valentini, Sara;Cabreiro, Filipe;Goss, Martin;Somogyvari, Milan;Piper, Matthew D.;Hoddinott, Matthew;Sutphin, George L.;Leko, Vid;McElwee, Joshua J.;Vazquez-Manrique, Rafael P.;Orfila, Anne-Marie;Ackerman, Daniel;Au, Catherine;Vinti, Giovanna;Riesen, Michele;Howard, Ken;Neri, Christian;Bedalov, Antonio;Kaeberlein, Matt;Soti, Csaba;Partridge, Linda;Gems, David
通讯作者：
Gems, David
影响因子：
5.5
作者：
Dunn AR;Hadad N;Neuner SM;Zhang JG;Philip VM;Dumitrescu L;Hohman TJ;Herskowitz JH;O'Connell KMS;Kaczorowski CC
通讯作者：
Kaczorowski CC
影响因子：
64.5
作者：
Fontana L;Partridge L
通讯作者：
Partridge L
影响因子：
3.3
作者：
Arya, Gunjan H.;Weber, Allison L.;Anholt, Robert R. H.
通讯作者：
Anholt, Robert R. H.