Social isolation through single housing negatively affects trabecular and cortical bone in adult male, but not female, C57BL/6J mice.
Social isolation through single housing negatively affects trabecular and cortical bone in adult male, but not female, C57BL/6J mice.
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DOI：
10.1016/j.bone.2023.116762
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发表时间：
2023-07
期刊：
影响因子：
4.1
通讯作者：
Motyl, Katherine J.
中科院分区：
文献类型：
--
作者：
V. Mountain, Rebecca;Langlais, Audrie L.;Hu, Dorothy;Baron, Roland;Lary, Christine W.;Motyl, Katherine J.
社会孤立是心理社会压力的一种有效形式，也是一个日益严重的公共卫生问题，特别是在老年人中。即使在2019冠状病毒病大流行显著增加了隔离和孤独的流行之前，研究人员就一直担心孤独的“流行病”正在上升。隔离与许多身心健康疾病的风险增加以及总体死亡风险增加有关。除了社会孤立，老年人患骨质疏松症和相关骨折的风险也更大。虽然研究人员已经调查了其他形式的心理社会压力对骨骼的负面影响，包括抑郁症和创伤后应激障碍，但社会孤立对骨骼的影响尚未得到彻底调查。本研究的目的是检验社会隔离会导致雄性和雌性C57 BL/6 J小鼠骨质流失的假设。将16周龄的小鼠随机分为社会隔离（1只小鼠/笼）或分组饲养（4只小鼠/笼）4周。社会隔离显著降低骨小梁（BV/TV，BMD，Tb。N.，TB. Th.）和皮质骨（Ct. Th.，Ct.Ar.，Ct.Ar./ Tt.A.，pMOI）参数。孤立的雄性小鼠有骨重建减少的迹象，表现为成骨细胞数量减少，成骨细胞相关基因表达和破骨细胞相关基因表达减少。然而，单独的雌性动物骨吸收相关基因表达增加，骨量无任何变化。总的来说，我们的数据表明，社会隔离对雄性小鼠的骨有负面影响，但对雌性小鼠没有影响，尽管雌性小鼠对骨吸收有暗示性影响。这些结果提供了关于隔离对骨骼影响的关键见解，并在我们应对与COVID-19大流行相关的社会隔离上升对健康的长期影响时具有关键的临床意义。
Social isolation is a potent form of psychosocial stress and is a growing public health concern, particularly among older adults. Even prior to the onset of the COVID-19 pandemic, which has significantly increased the prevalence of isolation and loneliness, researchers have been concerned about a rising “epidemic” of loneliness. Isolation is associated with an increased risk for many physical and mental health disorders and increased overall mortality risk. In addition to social isolation, older adults are also at greater risk for osteoporosis and related fractures. While researchers have investigated the negative effects of other forms of psychosocial stress on bone, including depression and PTSD, the effects of social isolation on bone have not been thoroughly investigated. The aim of this study was to test the hypothesis that social isolation would lead to bone loss in male and female C57BL/6J mice. 16-week-old mice were randomized into social isolation (1 mouse/cage) or grouped housing (4 mice/cage) for four weeks. Social isolation significantly decreased trabecular (BV/TV, BMD, Tb. N., Tb. Th.) and cortical bone (Ct.Th., Ct.Ar., Ct.Ar./Tt.Ar., pMOI) parameters in male, but not female mice. Isolated male mice had signs of reduced bone remodeling represented by reduced osteoblast numbers, osteoblast-related gene expression and osteoclast-related gene expression. However, isolated females had increased bone resorption-related gene expression, without any change in bone mass. Overall, our data suggest that social isolation has negative effects on bone in male, but not female mice, although females showed suggestive effects on bone resorption. These results provide critical insight into the effects of isolation on bone and have key clinical implications as we grapple with the long-term health impacts of the rise in social isolation related to the COVID-19 pandemic.
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DOI：
10.1007/s00198-016-3634-3
发表时间：
2016-10
期刊：
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
影响因子：
--
作者：
Iwaniec UT;Philbrick KA;Wong CP;Gordon JL;Kahler-Quesada AM;Olson DA;Branscum AJ;Sargent JL;DeMambro VE;Rosen CJ;Turner RT
通讯作者：
Turner RT
影响因子：
4.6
作者：
Laugesen K;Baggesen LM;Schmidt SAJ;Glymour MM;Lasgaard M;Milstein A;Sørensen HT;Adler NE;Ehrenstein V
通讯作者：
Ehrenstein V
影响因子：
3.8
作者：
Kunst RF;Langlais AL;Barlow D;Houseknecht KL;Motyl KJ
通讯作者：
Motyl KJ
影响因子：
5.6
作者：
Wuertz-Kozak K;Roszkowski M;Cambria E;Block A;Kuhn GA;Abele T;Hitzl W;Drießlein D;Müller R;Rapp MA;Mansuy IM;Peters EMJ;Wippert PM
通讯作者：
Wippert PM
影响因子：
6.2
作者：
Iwaniec, Urszula T.;Yuan, Dawn;Wronski, Thomas J.
通讯作者：
Wronski, Thomas J.