Proximity to traffic, ambient air pollution, and community noise in relation to incident rheumatoid arthritis.
Proximity to traffic, ambient air pollution, and community noise in relation to incident rheumatoid arthritis.
复制标题
DOI：
10.1289/ehp.1307413
复制
发表时间：
2014-10
影响因子：
10.4
通讯作者：
Brauer M
中科院分区：
文献类型：
--
作者：
De Roos AJ;Koehoorn M;Tamburic L;Davies HW;Brauer M
背景资料：类风湿性关节炎（RA）的风险与居住在交通附近有关;然而，有证据表明，空气污染可能不是这种关联的原因。噪音是另一种交通产生的暴露，尚未被研究为RA的风险因素。目的：我们调查了接近交通，环境空气污染和社区噪音有关RA在温哥华和维多利亚地区的不列颠哥伦比亚省，加拿大。方法：病例组和对照组是在一个成年人队列中确定的，该队列是使用健康保险登记记录组装的。从1999年到2002年的RA病例是通过诊断代码结合处方和医生类型（例如，风湿病学家）。对照组按年龄和性别与类风湿关节炎病例相匹配。根据研究人群的居住地邮政编码，将环境暴露分配给每个成员。我们使用条件Logistic回归估计相对风险，并对邮政编码处的收入中位数进行额外调整。结果如下：RA的发病率随着靠近交通而增加，与距离> 150 m的居住地相比，距离高速公路≤ 50 m的居住地的优势比（OR）为1.37（95% CI：1.11，1.68）。我们没有发现与交通相关的暴露，如PM2.5，氮氧化物或噪音。地面臭氧，这是最高的郊区，与RA的风险增加（OR = 1.26; 95%CI：1.18，1.36每四分位数范围增加）。结论：我们的研究证实了先前观察到的RA风险与交通接近度的相关性，并表明噪音水平和交通相关的空气污染物都不是这种关系的原因。对道路附近居民的邻里和个人相关性的进一步调查可能为RA的危险因素提供新的见解。引文：De鲁什AJ，Koehoorn M，Tambuic L，Davies HW，Brauer M. 2014.类风湿性关节炎发病与交通、环境空气污染和社区噪音的关系。环境健康展望122：1075-1080; http：dx.doi.org/10.1289/ehp.1307413
Background: The risk of rheumatoid arthritis (RA) has been associated with living near traffic; however, there is evidence suggesting that air pollution may not be responsible for this association. Noise, another traffic-generated exposure, has not been studied as a risk factor for RA. Objectives: We investigated proximity to traffic, ambient air pollution, and community noise in relation to RA in the Vancouver and Victoria regions of British Columbia, Canada. Methods: Cases and controls were identified in a cohort of adults that was assembled using health insurance registration records. Incident RA cases from 1999 through 2002 were identified by diagnostic codes in combination with prescriptions and type of physician (e.g., rheumatologist). Controls were matched to RA cases by age and sex. Environmental exposures were assigned to each member of the study population by their residential postal code(s). We estimated relative risks using conditional logistic regression, with additional adjustment for median income at the postal code. Results: RA incidence was increased with proximity to traffic, with an odds ratio (OR) of 1.37 (95% CI: 1.11, 1.68) for residence ≤ 50 m from a highway compared with residence > 150 m away. We found no association with traffic-related exposures such as PM2.5, nitrogen oxides, or noise. Ground-level ozone, which was highest in suburban areas, was associated with an increased risk of RA (OR = 1.26; 95% CI: 1.18, 1.36 per interquartile range increase). Conclusions: Our study confirms a previously observed association of RA risk with proximity to traffic and suggests that neither noise levels nor traffic-related air pollutants are responsible for this relationship. Additional investigation of neighborhood and individual correlates of residence near roadways may provide new insight into risk factors for RA. Citation: De Roos AJ, Koehoorn M, Tamburic L, Davies HW, Brauer M. 2014. Proximity to traffic, ambient air pollution, and community noise in relation to incident rheumatoid arthritis. Environ Health Perspect 122:1075–1080; http://dx.doi.org/10.1289/ehp.1307413
登录
查看更多内容
影响因子：
27.4
作者：
Hart JE;Källberg H;Laden F;Bellander T;Costenbader KH;Holmqvist M;Klareskog L;Alfredsson L;Karlson EW
通讯作者：
Karlson EW
影响因子：
5
作者：
Gan, Wen Qi;Davies, Hugh W.;Brauer, Michael
通讯作者：
Brauer, Michael
DOI：
10.1002/art.21077
发表时间：
2005-04-15
期刊：
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
影响因子：
--
作者：
Lacaille, D;Anis, AH;Esdaile, JM
通讯作者：
Esdaile, JM
影响因子：
--
作者：
Doran, MF;Pond, GR;Gabriel, SE
通讯作者：
Gabriel, SE
影响因子：
11.4
作者：
Henderson, Sarah B.;Beckerman, Bernardo;Brauer, Michael
通讯作者：
Brauer, Michael