Ambient air pollution exposures and risk of rheumatoid arthritis: results from the Swedish EIRA case-control study.
Ambient air pollution exposures and risk of rheumatoid arthritis: results from the Swedish EIRA case-control study.
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DOI：
10.1136/annrheumdis-2012-201587
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发表时间：
2013-06
影响因子：
27.4
通讯作者：
Karlson EW
中科院分区：
文献类型：
--
作者：
Hart JE;Källberg H;Laden F;Bellander T;Costenbader KH;Holmqvist M;Klareskog L;Alfredsson L;Karlson EW
环境因素可能在类风湿性关节炎（RA）的发展中发挥作用。我们在瑞典类风湿关节炎流行病学调查 (EIRA) 研究中检查了长期暴露于空气污染是否与 RA 风险相关。我们研究了 1,497 例 RA 病例和 2,536 例对照。预测了所有住宅区交通和家庭供暖产生的颗粒物 (PM10) 和气态污染物（SO2 和 NO2）的局部水平。我们研究了症状出现前不同时间点每种污染物的四分位距增加（PM10 为 2μg/m3、SO2 为 8μg/m3、NO2 为 9μg/m3）与所有 RA 风险以及类风湿因子 (RF) 和抗瓜氨酸蛋白抗体 (ACPA) RA 表型风险之间的关联。没有证据表明 PM10 会增加患 RA 的风险。气态污染物的 RA 总风险略有升高，但在调整吸烟和教育后，并无统计学意义（发病前 10 年 SO2 和 NO2 的比值比 (OR)=1.18 [95% 置信区间 (CI)：0.97–1.43]，OR=1.09 [95%CI：0.99–1.19]）。对于未受过大学教育且具有 ACPA-RA 表型的个体，观察到更高的风险。没有观察到斯德哥尔摩地区的空气污染与 RA 风险之间存在一致的总体关联。然而，有人建议，随着当地交通中的二氧化氮和家庭取暖源中的二氧化硫的增加，与 ACPA 表型的关联性更强，RA 发病的风险也会增加。
Environmental factors may play a role in the development of rheumatoid arthritis (RA). We examined whether long-term exposures to air pollution were associated with risk of RA in the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) Study. We studied 1,497 incident RA cases and 2,536 controls. Local levels of particulate matter (PM10) and gaseous pollutants (SO2 and NO2,) from traffic and home heating were predicted for all residential addresses. We examined the association of an interquartile range increase (2μg/m3 for PM10, 8μg/m3 for SO2, and 9μg/m3 for NO2) in each pollutant at different time points prior to symptom onset and average exposure with the risk of all RA and the risk of the rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) RA phenotypes. There was no evidence of an increased risk of RA with PM10. Total RA risks were modestly elevated for the gaseous pollutants, but were not statistically significant after adjustment for smoking and education (odds ratio (OR)=1.18 [95%confidence interval (CI): 0.97–1.43] and OR=1.09 [95%CI: 0.99–1.19] for SO2 and NO2 in the 10th year before onset). Stronger elevated risks were observed for individuals with less than a university education and with the ACPA- RA phenotype. No consistent overall associations between air pollution in the Stockholm area and risk for RA were observed. However, there was a suggestion of increased risks of RA incidence with increases in NO2 from local traffic and SO2 from home heating sources with stronger associations for the ACPA- phenotype.
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影响因子：
10.4
作者：
Jerrett M;Finkelstein MM;Brook JR;Arain MA;Kanaroglou P;Stieb DM;Gilbert NL;Verma D;Finkelstein N;Chapman KR;Sears MR
通讯作者：
Sears MR
DOI：
10.1164/rccm.200611-1627oc
发表时间：
2007-08-15
影响因子：
24.7
作者：
Chuang, Kai-Jen;Chan, Chang-Chuan;Tang, Chin-Sheng
通讯作者：
Tang, Chin-Sheng
影响因子：
--
作者：
Doran, MF;Pond, GR;Gabriel, SE
通讯作者：
Gabriel, SE
影响因子：
10.4
作者：
Bellander, T;Berglind, N;Järup, L
通讯作者：
Järup, L
影响因子：
10.4
作者：
Hart JE;Laden F;Puett RC;Costenbader KH;Karlson EW
通讯作者：
Karlson EW