The importance of REM sleep fragmentation in the effects of stress on sleep: Perspectives from preclinical studies.
The importance of REM sleep fragmentation in the effects of stress on sleep: Perspectives from preclinical studies.
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DOI：
10.1016/j.ynstr.2023.100588
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发表时间：
2024-01
影响因子：
5
通讯作者：
Bhatnagar, Seema
中科院分区：
文献类型：
--
作者：
Grafe, Laura;Miller, Katherine E.;Ross, Richard J.;Bhatnagar, Seema
心理压力会造成睡眠障碍。重要的是，创伤暴露的个体发展为创伤后应激障碍（PTSD）经常报告失眠和反复的噩梦。临床研究已经对这些睡眠障碍的机制提供了深入的了解。我们回顾了创伤后应激障碍的多导睡眠图发现，并确定了在创伤后应激障碍动物模型中所做的类似措施。关于快速眼动睡眠（REMS）对失眠和噩梦的影响，已有丰富的实证和理论文献，重点是REMS碎片化。对于未来压力诱发睡眠变化的研究，我们建议将重点放在紧张性、相位性和其他微结构性REMS测量上。还应利用睡眠脑电图的功率谱密度分析。具有高结构效度的动物模型可以提供性别和压力暴露时间作为调节变量的洞见。最终，具有转化潜力的临床前研究将改善与压力相关的睡眠障碍的治疗。
Psychological stress poses a risk for sleep disturbances. Importantly, trauma-exposed individuals who develop posttraumatic stress disorder (PTSD) frequently report insomnia and recurrent nightmares. Clinical studies have provided insight into the mechanisms of these sleep disturbances. We review polysomnographic findings in PTSD and identify analogous measures that have been made in animal models of PTSD. There is a rich empirical and theoretical literature on rapid eye movement sleep (REMS) substrates of insomnia and nightmares, with an emphasis on REMS fragmentation. For future investigations of stress-induced sleep changes, we recommend a focus on tonic, phasic and other microarchitectural REMS measures. Power spectral density analysis of the sleep EEG should also be utilized. Animal models with high construct validity can provide insight into gender and time following stressor exposure as moderating variables. Ultimately, preclinical studies with translational potential will lead to improved treatment for stress-related sleep disturbances.
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影响因子：
5
作者：
Nedelcovych MT;Gould RW;Zhan X;Bubser M;Gong X;Grannan M;Thompson AT;Ivarsson M;Lindsley CW;Conn PJ;Jones CK
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