Reduced γ range activity at REM sleep onset and termination in fear-conditioned Wistar-Kyoto rats.
Reduced γ range activity at REM sleep onset and termination in fear-conditioned Wistar-Kyoto rats.
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DOI：
10.1016/j.neulet.2011.02.003
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发表时间：
2011-04-08
影响因子：
2.5
通讯作者：
Morrison AR
中科院分区：
文献类型：
--
作者：
Laitman BM;Dasilva JK;Ross RJ;Tejani-Butt S;Morrison AR
最近对快速眼动睡眠（REMS）连续性的研究强调了进入和退出REMS的重要性。我们以前曾报道，与Wistar大鼠（WIS）相比，Wistar-Kyoto大鼠（WKY）对恐惧条件反射（FC）的反应具有更多片段化的REMS。脑电图（EEG）中的伽马振荡在注意力集中的时期在整个大脑中是同步的，并且大脑中细胞组装的这种同步可能代表时间绑定机制。因此，我们研究了FC对WKY与WIS中REMS转换时EEG伽马范围活动（30-50 Hz）的影响。在基线和再次暴露于恐惧诱导条件刺激时，在REMS发作前35 s至REMS发作后105 s（ARO）和REMS终止前85 s至REMS终止后35 s测量伽马范围内的相对功率（测量为总功率的百分比）。在基线记录后，大鼠接受十个音调，每个音调与电击脚共同终止。在预处理后第1天和第14天，将大鼠再次暴露于三种音调。快速傅立叶变换在伽马频域中创建功率谱数据。从平均4-5次REMS跃迁中提取相对功率。相对伽马功率在WIS中始终较高。第14天，在15 s和25 s ARO时，WKY的相对伽马功率较基线显著增加。WIS在第1天25 s ARO时显著增加。尽管相对伽马功率增加，WKY从未达到WIS所达到的水平。此外，在5 s BRT时，从基线至第14天，仅WKY的相对伽马功率显著降低。伽马射程活动可能表明维持REMS连续性的神经活动。REMS转换时的低相对伽马功率可能与FC后WKY的REMS碎片增加相关。
Recent investigations of rapid eye movement sleep (REMS) continuity have emphasized the importance of transitions both into and out of REMS. We have previously reported that, compared to Wistar rats (WIS), Wistar-Kyoto rats (WKY) responded to fear conditioning (FC) with more fragmented REMS. Gamma oscillations in the electroencephalogram (EEG) are synchronized throughout the brain in periods of focused attention, and such synchronization of cell assemblies in the brain may represent a temporal binding mechanism. Therefore, we examined the effects of FC on EEG gamma range activity (30–50 Hz) at REMS transitions in WKY compared to WIS. Relative power in the gamma range (measured as a percent of total power) at baseline and upon re-exposure to the fear-inducing conditioning stimulus was measured 35 s before REMS onset to 105 s after REMS onset (ARO) and 85 s before REMS termination (BRT) to 35 s after REMS termination. After baseline recording, rats received ten tones, each co-terminating with an electric foot shock. On Days 1 and 14 post-conditioning, rats were re-exposed to three tones. Fast-Fourier transforms created power spectral data in the gamma frequency domain. Relative power was extracted from an average of 4–5 REMS transitions. Relative gamma power was always higher in WIS. On Day 14, at 15 s and 25 s ARO, WKY had significant increases in relative gamma power from Baseline. WIS had a significant increase on Day 1 at 25 s ARO. Despite the increases in relative gamma power, WKY never achieved levels attained by WIS. Moreover, at 5 s BRT, only WKY had a significant decrease in relative gamma power from Baseline to Day 14. Gamma range activity may indicate neural activity underlying maintenance of REMS continuity. Low relative gamma power at REMS transitions may be associated with increased REMS fragmentation in WKY after FC.
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影响因子：
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