Running wheel activity protects against increased seizure susceptibility in ethanol withdrawn male rats.
Running wheel activity protects against increased seizure susceptibility in ethanol withdrawn male rats.
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DOI：
10.1016/j.pbb.2011.10.009
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发表时间：
2012-01
影响因子：
3.6
通讯作者：
Devaud, Leslie L.
中科院分区：
文献类型：
--
作者：
McCulley, Walter D., III;Walls, Shawn A.;Khurana, Ritu C.;Rosenwasser, Alan M.;Devaud, Leslie L.
乙醇戒断是一种烦躁不安的状况，由依赖个体终止乙醇摄入引起。常见的戒断症状包括焦虑、对刺激的反应性增加和癫痫发作易感性增加以及癫痫发作严重程度增加的风险。我们使用依赖和戒断的动物模型来研究戒断行为和潜在的神经生物学机制。多年来，我们已经量化了戊四氮癫痫发作阈值，作为在戒断一天和三天时对乙醇戒断的评估。通常情况下，我们看到癫痫发作阈值显著降低（对癫痫发作诱导的敏感性增加），雄性大鼠在戒断三天内持续存在。越来越多的证据表明，自愿锻炼可以保护身体和心理健康免受各种挑战，包括与乙醇有关的挑战。因此，目前的研究调查自愿轮运行癫痫易感性的影响，慢性乙醇管理和退出。我们发现，自愿轮运行衰减戊四氮诱导的癫痫发作与乙醇戒断观察到的敏感性增加，在一天和三天的时间点。这一结果特别有趣，因为能够接触到转轮的动物消耗了更多的含乙醇饮食。这些研究结果表明，慢性自愿轮运行降低了我们的动物模型中的酒精戒断的严重程度，并表明基于运动的干预措施可能在大量饮酒和酒精戒断的临床管理中具有一定的实用性。
Ethanol withdrawal is a dysphoric condition that arises from termination of ethanol intake by dependent individuals. Common withdrawal symptoms include anxiety, increased reactivity to stimuli and increased seizure susceptibility as well as the risk of increased seizure severity. We use an animal model of dependence and withdrawal to study withdrawal behaviors and potential underlying neurobiological mechanisms. For a number of years, we have quantified pentylenetetrazol seizure thresholds as an assessment of ethanol withdrawal at both one day and three days of withdrawal. Typically, we see a significant decrease in seizure threshold (increased sensitivity to seizure induction) that persists through three days of withdrawal for male rats. Increasing evidence indicates that voluntary exercise affords protection against various challenges to physical and psychological health, including ethanol-related challenges. Therefore, the current study investigated the effect of voluntary wheel running on seizure susceptibility following chronic ethanol administration and withdrawal. We found that voluntary wheel running attenuated the increased sensitivity to pentylenetetrazol-induced seizures observed with ethanol withdrawal, at both the one-day and three-day time points. This result was especially interesting as animals with access to the running wheels consumed more of the ethanol-containing diet. These findings showed that chronic voluntary wheel running reduces the severity of ethanol withdrawal in our animal model and suggest that exercise-based interventions may have some utility in the clinical management of heavy drinking and alcohol withdrawal.
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影响因子：
2.9
作者：
Devaud, LL;Fritschy, JM;Morrow, AL
通讯作者：
Morrow, AL
影响因子：
2.9
作者：
Nyhuis TJ;Masini CV;Sasse SK;Day HE;Campeau S
通讯作者：
Campeau S
DOI：
10.1124/jpet.106.107896
发表时间：
2007-01-01
影响因子：
3.5
作者：
Alele, P. E.;Devaud, L. L.
通讯作者：
Devaud, L. L.
影响因子：
3.6
作者：
Cagetti, E;Liang, J;Olsen, RW
通讯作者：
Olsen, RW
影响因子：
8
作者：
Moonat, Sachin;Starkman, Bela G.;Sakharkar, Amul;Pandey, Subhash C.
通讯作者：
Pandey, Subhash C.