Physical activity, but not environmental complexity, facilitates HPA axis response habituation to repeated audiogenic stress despite neurotrophin mRNA regulation in both conditions.
Physical activity, but not environmental complexity, facilitates HPA axis response habituation to repeated audiogenic stress despite neurotrophin mRNA regulation in both conditions.
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DOI：
10.1016/j.brainres.2010.09.038
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发表时间：
2010-11-29
期刊：
影响因子：
2.9
通讯作者：
Campeau S
中科院分区：
文献类型：
--
作者：
Nyhuis TJ;Masini CV;Sasse SK;Day HE;Campeau S
压力会加剧一些身体和心理疾病。自愿锻炼可以降低对许多与压力相关的疾病的易感性。在啮齿类动物中，自愿运动可以减少下丘脑-垂体-肾上腺皮质（HPA）轴对各种压力源的反应，并上调多种脑神经营养因子。关于自愿锻炼的一个重要问题是，其对压力下 HPA 轴激活减少的影响是由于身体活动本身，还是仅仅是由于跑步轮提供的环境复杂性增强所致。本研究比较了体力活动和环境复杂性（不会增加体力活动）对 HPA 轴习惯的影响，以及反复应激和脑神经营养蛋白 mRNA 表达的调节。在六周的时间里，雄性大鼠可以自由使用跑轮（运动组），给予 4 个反复交换的物体（增加环境复杂性组），或者安置在标准笼子中。第 7 周，动物连续 11 次每天暴露在 30 分钟的 98 dBA 噪音中。从噪声暴露后直接采集的血液中测量血浆皮质酮和促肾上腺皮质激素，并在第 11 天收集大脑、胸腺和肾上腺。尽管运动组和环境复杂性增强组的大鼠在几个大脑区域中表达较高水平的 BDNF 和 NGF mRNA，但只有运动动物对重复的听源应激表现出更快的糖皮质激素习惯。这些结果表明，独立于其他环境操纵的自愿锻炼可以降低对压力的敏感性。
Stress exacerbates several physical and psychological disorders. Voluntary exercise can reduce susceptibility to many of these stress-associated disorders. In rodents, voluntary exercise can reduce hypothalamic-pituitary-adrenocortical (HPA) axis activity in response to various stressors as well as upregulate several brain neurotrophins. An important issue regarding voluntary exercise is whether its effect on the reduction of HPA axis activation in response to stress is due to the physical activity itself or simply the enhanced environmental complexity provided by the running wheels. The present study compared the effects of physical activity and environmental complexity (that did not increase physical activity) on HPA axis habituation to repeated stress and modulation of brain neurotrophin mRNA expression. For six weeks, male rats were given free access to running wheels (exercise group), given 4 objects that were repeatedly exchanged (increased environmental complexity group), or housed in standard cages. On week 7, animals were exposed to 11 consecutive daily 30-min sessions of 98-dBA noise. Plasma corticosterone and adrenocorticotropic hormone were measured from blood collected directly after noise exposures, and brains, thymi, and adrenal glands were collected on day 11. Although rats in both the exercise and enhanced environmental complexity groups expressed higher levels of BDNF and NGF mRNA in several brain regions, only exercise animals showed quicker glucocorticoid habituation to repeated audiogenic stress. These results suggest that voluntary exercise, independently from other environmental manipulations, accounts for the reduction in susceptibility to stress.
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影响因子：
2.9
作者：
Day, Heidi E. W.;Kryskow, Elisa M.;Nyhuis, Tara J.;Herlihy, Lauren;Campeau, Serge
通讯作者：
Campeau, Serge
影响因子：
4.8
作者：
MAKINO, S;SCHULKIN, J;GOLD, PW
通讯作者：
GOLD, PW
影响因子：
3.2
作者：
LUO, X;KISS, A;AGUILERA, G
通讯作者：
AGUILERA, G
影响因子：
4.1
作者：
Dunn, AL;Trivedi, MH;O'Neal, HA
通讯作者：
O'Neal, HA
影响因子：
2.9
作者：
Campeau, Serge;Nyhuis, Tara J.;Kryskow, Elisabeth M.;Masini, Cher V.;Babb, Jessica A.;Sasse, Sarah K.;Greenwood, Benjamin N.;Fleshner, Monika;Day, Heidi E. W.
通讯作者：
Day, Heidi E. W.