Amelioration of Ethanol-Induced Hepatitis by Magnesium Isoglycyrrhizinate through Inhibition of Neutrophil Cell Infiltration and Oxidative Damage.
Amelioration of Ethanol-Induced Hepatitis by Magnesium Isoglycyrrhizinate through Inhibition of Neutrophil Cell Infiltration and Oxidative Damage.
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异甘草酸镁通过抑制中性粒细胞浸润和氧化损伤改善乙醇诱发的肝炎
DOI：
10.1155/2017/3526903
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发表时间：
2017
影响因子：
4.6
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Wang Y;Zhang Z;Wang X;Qi D;Qu A;Wang G
酒精性肝病（ALD）是全球肝脏相关发病率和死亡率的主要原因。没有有效的治疗方法来防止疾病的进展。异甘草酸镁（MgIG）具有有效的抗炎、抗氧化和保肝活性，在亚洲被用于治疗肝脏疾病。在这项研究中，我们研究了MgIG是否可以保护小鼠免受酒精诱导的肝损伤。本研究采用新建立的慢性酒精加酒精灌胃模型，研究MgIG在ALD中的作用。采用血清肝酶水平、H&E染色、免疫组化染色、流式细胞术分析和实时荧光定量PCR评价肝损伤和炎症。我们发现，MgIG显着改善慢性加酗酒酒精喂养肝损伤，如血清丙氨酸转氨酶和天冬氨酸转氨酶水平降低，减少中性粒细胞浸润。其原因可能是由于MgIG治疗降低了促炎细胞因子和趋化因子的表达。MgIG的肝保护作用与抑制中性粒细胞ROS产生以及肝细胞氧化应激有关。MgIG可能通过调节中性粒细胞活性和肝脏氧化应激，在保护慢性加酒精摄入诱导的肝损伤中发挥关键作用。
Alcoholic liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide. There is no effective treatment to prevent the disease progression. Magnesium isoglycyrrhizinate (MgIG) showed potent anti-inflammatory, antioxidant, and hepatoprotective activities and was used for treating liver diseases in Asia. In this study, we examined whether MgIG could protect mice against alcohol-induced liver injury. The newly developed chronic plus binge ethanol feeding model was used to study the role of MgIG in ALD. Serum liver enzyme levels, H&E staining, immunohistochemical staining, flow cytometric analysis, and real-time PCR were used to evaluate the liver injury and inflammation. We showed that MgIG markedly ameliorated chronic plus binge ethanol feeding liver injury, as shown by decreased serum alanine transaminase and aspartate aminotransferase levels and reduced neutrophil infiltration. The reason may be attributed to the reduced expression of proinflammatory cytokines and chemokines with the treatment of MgIG. The hepatoprotective effect of MgIG was associated with suppression of neutrophil ROS production as well as hepatocellular oxidative stress. MgIG may play a critical role in protecting against chronic plus binge ethanol feeding-induced liver injury by regulating neutrophil activity and hepatic oxidative stress.
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将酒精性肝病的致病机制与临床表型联系起来。
影响因子：
29.4
作者：
Nagy LE;Ding WX;Cresci G;Saikia P;Shah VH
通讯作者：
Shah VH
影响因子：
24.5
作者：
Gao B;Xu M
通讯作者：
Xu M
异甘草酸镁通过抑制磷脂酶 A2/花生四烯酸途径的抗炎活性
影响因子：
5.1
作者：
Xie, Chunfeng;Li, Xiaoting;Zhong, Caiyun
通讯作者：
Zhong, Caiyun
影响因子：
2.3
作者：
Jaeschke, H
通讯作者：
Jaeschke, H
酒精性肝病：发病机制和新的治疗靶点。
影响因子：
29.4
作者：
Gao B;Bataller R
通讯作者：
Bataller R