UK Biobank: a globally important resource for cancer research.
UK Biobank: a globally important resource for cancer research.
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DOI：
10.1038/s41416-022-02053-5
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发表时间：
2023-02
影响因子：
8.8
通讯作者：
Allen, Naomi E.
中科院分区：
文献类型：
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作者：
Conroy, Megan C.;Lacey, Ben;Besevic, Jelena;Omiyale, Wemimo;Feng, Qi;Effingham, Mark;Sellers, Jonathan;Sheard, Simon;Pancholi, Mahesh;Gregory, Gareth;Busby, John;Collins, Rory;Allen, Naomi E.
英国生物银行是一项大规模的前瞻性研究，具有深入的表型和基因组数据。其开放获取政策允许来自学术界或工业界的世界各地的研究人员出于公共利益进行卫生研究。在2006年至2010年期间，该研究从英国普通人群中招募了502,000名年龄在40-69岁之间的成年人。在登记时，参与者提供了广泛的因素信息，进行了物理测量，并收集了生物样本（血液，尿液和唾液）进行长期储存。研究人员对参与者进行了十多年的跟踪调查，记录了52000多例癌症病例。通过重复评估、基于网络的问卷调查、多模式成像以及将储存的生物样本转换为基因组和其他“基因组”数据，该研究继续得到加强。这项研究已经证明了它在研究癌症决定因素方面的价值，未来计划的增强将使该资源对癌症研究人员更有价值。目前，全球有超过26,000名研究人员正在使用这些数据，进行广泛的癌症研究。英国生物银行在改变我们对癌症发展和进展原因的理解方面具有独特的地位，并在未来几十年推动癌症治疗和预防的改进。
UK Biobank is a large-scale prospective study with deep phenotyping and genomic data. Its open-access policy allows researchers worldwide, from academia or industry, to perform health research in the public interest. Between 2006 and 2010, the study recruited 502,000 adults aged 40–69 years from the general population of the United Kingdom. At enrolment, participants provided information on a wide range of factors, physical measurements were taken, and biological samples (blood, urine and saliva) were collected for long-term storage. Participants have now been followed up for over a decade with more than 52,000 incident cancer cases recorded. The study continues to be enhanced with repeat assessments, web-based questionnaires, multi-modal imaging, and conversion of the stored biological samples to genomic and other ‘–omic’ data. The study has already demonstrated its value in enabling research into the determinants of cancer, and future planned enhancements will make the resource even more valuable to cancer researchers. Over 26,000 researchers worldwide are currently using the data, performing a wide range of cancer research. UK Biobank is uniquely placed to transform our understanding of the causes of cancer development and progression, and drive improvements in cancer treatment and prevention over the coming decades.
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影响因子：
64.8
作者：
Bycroft C;Freeman C;Petkova D;Band G;Elliott LT;Sharp K;Motyer A;Vukcevic D;Delaneau O;O'Connell J;Cortes A;Welsh S;Young A;Effingham M;McVean G;Leslie S;Allen N;Donnelly P;Marchini J
通讯作者：
Marchini J
DOI：
10.1007/s10552-021-01391-8
发表时间：
2021-04
期刊：
Cancer causes & control : CCC
影响因子：
--
作者：
Cote DJ;Smith-Warner SA;Creed JH;Furtado J;Gerke T;Wang M;Kim Y;Stampfer MJ;Egan KM
通讯作者：
Egan KM
影响因子：
56.9
作者：
Akbari, Parsa;Gilani, Ankit;Sosina, Olukayode;Kosmicki, Jack A.;Khrimian, Lori;Fang, Yi-Ya;Persaud, Trikaldarshi;Garcia, Victor;Sun, Dylan;Li, Alexander;Mbatchou, Joelle;Locke, Adam E.;Benner, Christian;Verweij, Niek;Lin, Nan;Hossain, Sakib;Agostinucci, Kevin;Pascale, Jonathan, V;Dirice, Ercument;Dunn, Michael;Kraus, William E.;Shah, Svati H.;Chen, Yii-Der, I;Rotter, Jerome, I;Rader, Daniel J.;Melander, Olle;Still, Christopher D.;Mirshahi, Tooraj;Carey, David J.;Berumen-Campos, Jaime;Kuri-Morales, Pablo;Alegre-Diaz, Jesus;Torres, Jason M.;Emberson, Jonathan R.;Collins, Rory;Balasubramanian, Suganthi;Hawes, Alicia;Jones, Marcus;Zambrowicz, Brian;Murphy, Andrew J.;Paulding, Charles;Coppola, Giovanni;Overton, John D.;Reid, Jeffrey G.;Shuldiner, Alan R.;Cantor, Michael;Kang, Hyun M.;Abecasis, Goncalo R.;Karalis, Katia;Economides, Aris N.;Marchini, Jonathan;Yancopoulos, George D.;Sleeman, Mark W.;Altarejos, Judith;Della Gatta, Giusy;Tapia-Conyer, Roberto;Schwartzman, Michal L.;Baras, Aris;Ferreira, Manuel A. R.;Lotta, Luca A.
通讯作者：
Lotta, Luca A.
影响因子：
8.8
作者：
Brown KF;Rumgay H;Dunlop C;Ryan M;Quartly F;Cox A;Deas A;Elliss-Brookes L;Gavin A;Hounsome L;Huws D;Ormiston-Smith N;Shelton J;White C;Parkin DM
通讯作者：
Parkin DM
影响因子：
4.9
作者：
Ahmed, Muktar;Mulugeta, Anwar;Hypponen, Elina
通讯作者：
Hypponen, Elina