Circulating lipids and glioma risk: results from the UK Biobank, Nurses' Health Study, and Health Professionals Follow-Up Study.
Circulating lipids and glioma risk: results from the UK Biobank, Nurses' Health Study, and Health Professionals Follow-Up Study.
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DOI：
10.1007/s10552-021-01391-8
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Egan KM
中科院分区：
文献类型：
--
作者：
Cote DJ;Smith-Warner SA;Creed JH;Furtado J;Gerke T;Wang M;Kim Y;Stampfer MJ;Egan KM
关于胆固醇是否在神经胶质瘤的发病机制中起作用，证据不一。我们在三个前瞻性队列中探索了循环血脂与神经胶质瘤风险之间的关系。使用来自英国生物库的前瞻性数据，我们在多变量(MV)调整的COX比例风险模型中检验了总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和甘油三酯(TG)与胶质瘤风险的关系。在护士健康研究(NHS)和卫生专业人员随访研究(HPFS)中，我们进行了一项匹配的嵌套病例对照研究，以检查这些相同的相关性。在英国生物库，在2358,964人年中发生了490例神经胶质瘤。TC与脑胶质瘤风险无明显相关性(MV HR=1.20，95%CI：0.89~1.61，P趋势=0.24)。在4年滞后分析中(n=229)，男性高TC与脑胶质瘤的风险显著相关(MV HR=2.26，95%CI：1.32-3.89，p-趋势=0.002)，而女性(MV HR=1.28，95%CI：0.61-2.68，p-趋势=0.72)与此无关联；在NHS/HPFS中，没有发现胆固醇和胶质瘤风险之间的显著关联。未发现与甘油三酯显著相关。在英国生物库中，在四年的滞后分析中，较高的诊断前TC和HDLC水平与较高的胶质瘤风险相关，但在非滞后分析中，仅在男性中不相关。这些发现值得进一步研究，因为几乎没有危险因素，也没有可靠的胶质瘤风险生物标志物。
Evidence is mixed on whether cholesterol plays a role in the pathogenesis of glioma. We explored the associations between circulating lipids and glioma risk in three prospective cohorts. Using prospective data from the UK Biobank, we examined the associations of total cholesterol (TC), high- and low-density lipoprotein cholesterol (HDL-C, LDL-C), and triglycerides (TG) with glioma risk in multivariable (MV)-adjusted Cox proportional hazards models. Within the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS), we carried out a matched, nested case-control study to examine these same associations. In the UK Biobank, 490 gliomas accrued over 2,358,964 person-years. TC was not significantly associated with glioma risk (MV HR=1.20, 95%CI: 0.89-1.61 for highest quartile vs. lowest, p-trend=0.24). In four-year lagged analyses (n=229), higher TC was associated with significantly higher risk of glioma in men (MV HR=2.26, 95%CI: 1.32-3.89, p-trend=0.002) but not women (MV HR =1.28, 95%CI: 0.61-2.68, p-trend=0.72); similar findings emerged for HDL-C and, to a lesser extent, LDL-C. In the NHS/HPFS, no significant associations were found between cholesterol and glioma risk. No significant associations were identified for TG. In the UK Biobank, higher prediagnostic TC and HDL-C levels were associated with higher risk of glioma in four-year lagged analyses, but not in non-lagged analyses, in men only. These findings merit further investigation, given that there are few risk factors and no reliable biomarkers of risk identified for glioma.
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影响因子：
45.3
作者：
Yuan, Chen;Qian, Zhi Rong;Wolpin, Brian M.
通讯作者：
Wolpin, Brian M.
DOI：
10.1158/1055-9965.epi-10-1250
发表时间：
2011-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Khalili H;Wolpin BM;Huang ES;Giovannucci EL;Kraft P;Fuchs CS;Chan AT
通讯作者：
Chan AT
影响因子：
50.3
作者：
Villa GR;Hulce JJ;Zanca C;Bi J;Ikegami S;Cahill GL;Gu Y;Lum KM;Masui K;Yang H;Rong X;Hong C;Turner KM;Liu F;Hon GC;Jenkins D;Martini M;Armando AM;Quehenberger O;Cloughesy TF;Furnari FB;Cavenee WK;Tontonoz P;Gahman TC;Shiau AK;Cravatt BF;Mischel PS
通讯作者：
Mischel PS
影响因子：
7.7
作者：
NEUGUT, AI;FINK, DJ;RADIN, D
通讯作者：
RADIN, D
影响因子：
105.7
作者：
SMITH, GD;SHIPLEY, MJ
通讯作者：
SHIPLEY, MJ