Genetics of reproductive isolation in the Drosophila simulans clade: complex epistasis underlying hybrid male sterility.
Genetics of reproductive isolation in the Drosophila simulans clade: complex epistasis underlying hybrid male sterility.
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模拟果蝇进化枝生殖隔离的遗传学：杂种雄性不育的复杂上位性。
DOI：
10.1093/genetics/137.1.175
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发表时间：
1994
期刊：
影响因子：
3.3
通讯作者：
Wu,CI
中科院分区：
文献类型：
--
作者：
Cabot,EL;Davis,AW;Johnson,NA;Wu,CI
我们已经分析了不育与渐渗的远端四分之一的X染色体从毛里求斯果蝇或果蝇sechellia到果蝇simulans的基因组中使用一系列可见的和DNA标记。因为在果蝇杂交种中，雄性不育通常是完全的，并且通常与杂交中使用的几个标记中的每一个紧密连锁，所以通常假设一个简单的遗传基础。在我们的低分辨率定位实验中，我们不能拒绝零假设，即从D。mauritiana或D. sechellia是男性不育的原因。然而，高分辨率绘图揭示了一幅复杂得多的画面。至少有三个不同的因素，从D。mauritiana和D. sechellia，被鉴定为需要共同存在以赋予完全的不育性。每一个单独的因素本身是相对无效的，在造成不育，甚至部分生精缺陷。此外，在D. mauritiana比D. sechellia。在这些观察的基础上，我们提出了一个模型，表明多位点弱等位基因相互作用是一个非常常见的原因密切相关的物种之间的生殖不相容。我们还提出了理论论据和经验证据，反对外推种内分析的结果来解释物种差异的遗传基础。讨论了该模型对物种差异进化理论的影响，以及在分子水平上理解杂种不育/不活力机制的尝试。
We have analyzed the sterility associated with introgressions of the distal one-fourth of the X chromosome from either Drosophila mauritiana or Drosophila sechellia into the genome of Drosophila simulans using a series of visible and DNA markers. Because in Drosophila hybrids, male sterility is usually complete and is often tightly linked with each of several markers used in crosses, a simple genetic basis has generally been assumed. In our low resolution mapping experiment, we were not able to reject the null hypothesis that a single gene, introgressed from either D. mauritiana or D. sechellia, is the cause of male sterility. High resolution mapping, however, reveals a much more complex picture. At least three distinct factors from D. mauritiana, or two from D. sechellia, were identified that need to be jointly present to confer full sterility. Each individual factor by itself is relatively ineffective in causing sterility, or even a partial spermatogenic defect. Moreover, there appear to be more sterility factors on comparable introgressions from D. mauritiana than from D. sechellia. On the basis of these observations, we propose a model which suggests that multilocus weak allele interactions are a very common cause of reproductive incompatibility between closely related species. We also present theoretical argument and empirical evidence against extrapolating the results of within-species analysis to interpret the genetic basis of species differences. The implications of this model on the theories of evolution of species differences and the attempt to understand the mechanisms of hybrid sterility/inviability at the molecular level are discussed.
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果蝇 PSEUDOOBSCURA 和 D. PERSIMILIS 的性别比和标准排列之间广泛遗传分化的证据以及杂种不育因子的鉴定。
影响因子：
3.3
作者：
Chung;A. Beckenbach
通讯作者：
A. Beckenbach
果蝇 bicoid 基因的分子分析：鉴定 bicoid mRNA 编码区和非编码区的保守结构域。
DOI：
10.1002/j.1460-2075.1990.tb07490.x
发表时间：
1990
期刊：
The EMBO journal
影响因子：
--
作者：
Seeger,MA;Kaufman,TC
通讯作者：
Kaufman,TC
结合经典遗传和高分辨率二维电泳方法来评估影响果蝇和果蝇杂交雄性不育的基因数量。
影响因子：
3.3
作者：
Lingwen Zeng;Rama S. Singh
通讯作者：
Rama S. Singh
影响因子：
2.7
作者：
M. Zalokar;C. Audit;I. Erk
通讯作者：
I. Erk
果蝇物种复合体内多个基因座 DNA 序列变异的群体遗传学和系统发育学。
影响因子：
10.7
作者：
J. Hey;R. Kliman
通讯作者：
R. Kliman