Population genetics and phylogenetics of DNA sequence variation at multiple loci within the Drosophila melanogaster species complex.
Population genetics and phylogenetics of DNA sequence variation at multiple loci within the Drosophila melanogaster species complex.
复制标题
果蝇物种复合体内多个基因座 DNA 序列变异的群体遗传学和系统发育学。
DOI：
10.1093/oxfordjournals.molbev.a040044
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发表时间：
1993
影响因子：
10.7
通讯作者：
R. Kliman
中科院分区：
文献类型：
--
作者：
J. Hey;R. Kliman
对来自四个物种（黑腹果蝇、模拟果蝇、毛里求斯果蝇和塞舌尔果蝇）各六个个体的基因组的两个区域（zeste 基因座的 1-kbp 部分和卵黄蛋白 2 基因座的 1.1-kbp 部分）进行了测序。物种和菌株与之前对周期基因座 1.9-kbp 区域的研究相同。没有发现最近的平衡或定向选择或物种之间选定差异积累的证据。卵黄蛋白2具有高水平的氨基酸置换变异和低水平的同义变异，而zeste则具有相反的模式。这种对比与基因功能和密码子偏倚模式的信息一致。多态性水平与有效种群大小的排名一致，从低到高，按以下顺序：D. sechellia、D. melanogaster、D. mauritiana 和 D. simulans。明显的物种关系与时期轨迹研究所暗示的非常相似。特别是，D. simulans 似乎是一个庞大的种群，仍在分离 D. mauritiana 和 D. sechellia 分离之前出现的变异。据估计，祖先 D. melanogaster 与其他物种的分离发生了 2.5-3.4 Mya。 D. sechellia 和 D. mauritiana 与祖先 D. simulans 的分离似乎发生了 0.58-0.86 Mya，其中 D. mauritiana 与祖先 D. simulans 的分离比 D. sechellia 晚 0.1 Myr。
Two regions of the genome, a 1-kbp portion of the zeste locus and a 1.1-kbp portion of the yolk protein 2 locus, were sequenced in six individuals from each of four species: Drosophila melanogaster, D. simulans, D. mauritiana, and D. sechellia. The species and strains were the same as those of a previous study of a 1.9-kbp region of the period locus. No evidence was found for recent balancing or directional selection or for the accumulation of selected differences between species. Yolk protein 2 has a high level of amino acid replacement variation and a low level of synonymous variation, while zeste has the opposite pattern. This contrast is consistent with information on gene function and patterns of codon bias. Polymorphism levels are consistent with a ranking of effective population sizes, from low to high, in the following order: D. sechellia, D. melanogaster, D.mauritiana, and D. simulans. The apparent species relationships are very similar to those suggested by the period locus study. In particular, D. simulans appears to be a large population that is still segregating variation that arose before the separation of D. mauritiana and D. sechellia. It is estimated that the separation of ancestral D. melanogaster from the other species occurred 2.5-3.4 Mya. The separations of D. sechellia and D. mauritiana from ancestral D. simulans appear to have occurred 0.58-0.86 Mya, with D. mauritiana having diverged from ancestral D. simulans 0.1 Myr more recently than D. sechellia.
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