Transcriptome analysis of the interferon-signature defining the autoimmune process of Sjögren's syndrome.
Transcriptome analysis of the interferon-signature defining the autoimmune process of Sjögren's syndrome.
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DOI：
10.1111/j.1365-3083.2012.02749.x
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发表时间：
2012-09
影响因子：
3.7
通讯作者：
Nguyen CQ
中科院分区：
文献类型：
--
作者：
Peck AB;Nguyen CQ
人类的干燥综合征（SS）和小鼠模型中的SS样（SjS样）疾病的特征在于针对唾液腺和泪腺的慢性免疫攻击，导致外分泌功能障碍。反复观察到的SS和SjS样疾病的一个特征是I型（α/β）和II型（γ）干扰素（IFN）的强烈上调表达。此外，最近的全球转录组研究已经确定了各种干扰素刺激的基因（ISG）转录差异表达的SS患者和小鼠模型的组织表现出SJS样疾病。对这些转录组数据库的分析表明，差异表达基因的集合是高度受限的，这表明在疾病的发展和发作期间激活（或抑制）的ISG中存在独特的特异性。因此，这些观察结果导致SS和SJS样疾病被指定为“干扰素特征”疾病。虽然SS和SJS样疾病可以被指定为这样，但很少有人努力确定干扰素信号相对于自身炎症可能意味着什么，以及它是否可能直接指向潜在的病因病理学机制。在这里，我们回顾这些有限的数据，并提供了一个模型，这些基因的产品如何相互作用的分子和生物学定义SS病理的关键细节。
Sjögren’s syndrome (SS) of humans and SS-like (SjS-like) diseases in mouse models are characterized by chronic immune attacks against the salivary and lacrimal glands leading to exocrine dysfunction. One characteristic of SS and SjS-like diseases repeatedly observed is a strong upregulated expression of both the type I (α/β) and type II (γ) interferons (IFNs). In addition, recent global transcriptome studies have identified a variety of IFN-stimulated gene (ISG) transcripts differentially expressed in tissues of SS patients and mouse models exhibiting SjS-like disease. Analyses of these transcriptome databases indicate that the sets of differentially expressed genes are highly restricted, suggesting that there is a unique specificity in ISGs activated (or suppressed) during development and onset of disease. As a result, these observations have led to both SS and SjS-like diseases being designated as ‘interferon-signature’ diseases. While SS and SjS-like diseases may be designated as such, very little effort has been made to determine what an interferon-signature might signify relative to autoinflammation and whether it might point directly to an underlying etiopathological mechanism. Here, we review these limited data and provide a model of how the products of these genes interact molecularly and biologically to define critical details of SS pathology.
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发表时间：
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