AUTS2 in the nucleus accumbens is essential for heroin-induced behavioral sensitization
AUTS2 in the nucleus accumbens is essential for heroin-induced behavioral sensitization
复制标题
伏隔核中的AUTS2对于海洛因诱导的行为敏化至关重要
DOI：
10.1016/j.neuroscience.2016.07.007
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发表时间：
2016-10
期刊：
影响因子：
3.3
通讯作者：
JIANGHUA LAI
中科院分区：
文献类型：
--
作者：
YONGSHENG ZHU;BO XING;WEI DANG;YUANYUAN JI;PENG YAN;YUNXIAO LI;XIAOMENG QIAO;JIANGHUA LAI
Autism susceptibility candidate 2 (AUTS2) is a gene associated with autism and mental retardation. Recent studies have suggested an association of theAUTS2gene with heroin dependence, and reducedAUTS2gene expression may confer increased susceptibility to heroin dependence. However, the functional role of the AUTS2 protein in regulating enduring neuroadaptations in response to heroin exposure has not been established. Here, we investigated the effects of acute and chronic heroin exposure on AUTS2 mRNA and protein expression in the nucleus accumbens (NAc) and caudate-putamen (CPu) to determine whether changes in AUTS2 expression are associated with heroin-induced locomotor sensitization in mice. Moreover, we explored whether AUST2 knockdown affects heroin-induced locomotor sensitization. AUTS2 mRNA and protein expression in the NAc, but not the CPu, was decreased after chronic heroin (1 mg/kg) administration. In the NAc, the expression of heroin-induced locomotor sensitization was enhanced through the lentiviral-AUTS2-shRNA-mediated knockdown of AUTS2, while the overexpression of AUTS2 attenuated the locomotor-stimulant effects of heroin. Together, these results indicate that AUTS2 in the NAc, but not the CPu, suppresses the initiation and expression of heroin-induced behavioral sensitization, suggesting that AUST2 may be a potential target for the treatment of heroin dependence.
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影响因子：
4.2
作者：
Zhu, Jie;Chen, Yanjiong;Zhao, Na;Cao, Guofen;Dang, Yonghui;Han, Wei;Xu, Ming;Chen, Teng
通讯作者：
Chen, Teng
影响因子：
4.3
作者：
Rothwell PE
通讯作者：
Rothwell PE
DOI：
10.4238/2015.january.16.1
发表时间：
2015-01
期刊：
Genetics and molecular research : GMR
影响因子：
--
作者：
Y. Wang;S. Wei;Y. Zhu;B. Zhao;X. Xun;J. Lai
通讯作者：
Y. Wang;S. Wei;Y. Zhu;B. Zhao;X. Xun;J. Lai
影响因子：
1.4
作者：
Brian Johnson;Scott F Ulberg;Swati Shivale;J. Donaldson;Ben Milczarski;S. Faraone
通讯作者：
Brian Johnson;Scott F Ulberg;Swati Shivale;J. Donaldson;Ben Milczarski;S. Faraone
慢性乙醇暴露后大鼠伏隔核中 NMDAR1-CaMKII-MAPK 的差异磷酸化
影响因子：
2.5
作者：
Zhao Bin;Wang YunPeng;Li Yunxiao;Qiao Xiaomeng;Yan Peng;Zhu Yongsheng;Lai Jianghua
通讯作者：
Lai Jianghua