Genetic and environmental determinants of the susceptibility of Amerindian derived populations for having hypertriglyceridemia.
Genetic and environmental determinants of the susceptibility of Amerindian derived populations for having hypertriglyceridemia.
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DOI：
10.1016/j.metabol.2014.03.012
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发表时间：
2014-07
影响因子：
9.8
通讯作者：
Pajukanta, Paeivi
中科院分区：
文献类型：
--
作者：
Aguilar-Salinas, Carlos A.;Tusie-Luna, Teresa;Pajukanta, Paeivi
在这里，我们讨论了潜在的解释高血压的患病率较高的人群与美洲印第安人的背景。虽然环境因素是触发因素，但寻找与种族有关的因素，解释美洲印第安人的易感性增加，是一个有前途的研究领域。西班牙裔人群高脂血症的遗传学研究面临着一些挑战。种族可能是证明遗传关联的一个主要混杂变量。尽管如此，对西班牙裔高脂血症的研究还是做出了重大贡献。两份全球妇女福利组织的报告专门包括墨西哥混血儿。在高加索人中报告的50%的关联可以推广到墨西哥人，但在许多情况下，墨西哥领先的SNP与欧洲人报告的不同。两份报告均包括与载脂蛋白B或甘油三酯浓度的新关联。墨西哥人的易感性等位基因频率高于欧洲人，其中几个基因对甘油三酯水平影响最大。一个例子是APOA 5中的SNP rs964184。对于ANGPTL3和TIMD4变体观察到相同的趋势。总之，我们假设，在生活方式发生重大变化的美洲印第安人人群中，高脂血症的遗传决定因素的研究可能被证明是一个很好的资源，以确定新的基因和途径与高脂血症。
Here, we discuss potential explanations for the higher prevalence of hypertriglyceridemia in populations with an Amerindian background. Although environmental factors are the triggers, the search for the ethnic related factors that explains the increased susceptibility of the Amerindians is a promising area for research. The study of the genetics of hypertriglyceridemia in Hispanic populations faces several challenges. Ethnicity could be a major confounding variable to prove genetic associations. Despite that, the study of hypertriglyceridemia in Hispanics has resulted in significant contributions. Two GWAS reports have exclusively included Mexican mestizos. Fifty percent of the associations reported in Caucasians could be generalized to the Mexicans, but in many cases the Mexican lead SNP was different than that reported in Europeans. Both reports included new associations with apo B or triglycerides concentrations. The frequency of susceptibility alleles in Mexicans is higher than that found in Europeans for several of the genes with the greatest effect on triglycerides levels. An example is the SNP rs964184 in APOA5. The same trend was observed for ANGPTL3 and TIMD4 variants. In summary, we postulate that the study of the genetic determinants of hypertriglyceridemia in Amerindian populations which have major changes in their lifestyle, may prove to be a great resource to identify new genes and pathways associated with hypertriglyceridemia.
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影响因子：
120.7
作者：
Carroll, Margaret D.;Kit, Brian K.;Mussolino, Michael E.
通讯作者：
Mussolino, Michael E.
影响因子：
8.7
作者：
Love, MW;Craddock, AL;Dawson, PA
通讯作者：
Dawson, PA
影响因子：
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作者：
Aguilar, CA;Talavera, G;Rull, JA
通讯作者：
Rull, JA
影响因子：
1.9
作者：
Huertas-Vázquez, A;del Rincón, JP;Tusié-Luna, MT
通讯作者：
Tusié-Luna, MT
系统遗传学方法暗示了USF1，FADS3和其他因果候选基因的家族性高脂血症。
影响因子：
4.5
作者：
Plaisier CL;Horvath S;Huertas-Vazquez A;Cruz-Bautista I;Herrera MF;Tusie-Luna T;Aguilar-Salinas C;Pajukanta P
通讯作者：
Pajukanta P